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Intervention
Are supplemental vitamins C and E, beta-carotene and selenium safe to take with Simvastatin-niacin drug combinations?
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Conclusion
Supplemental Vitamin C and E, Beta-carotene, and Selenium should not be taken with Simvastatin-Niacin drug combination because the combination of these antioxidants may lower HDL2-C, a beneficial subfraction of HDL-C.
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Grade: II
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
In patients at risk for lung cancer, what effect does supplemental Beta-carotene have on the risk for all-cause mortality and cardiovascular death?-
Conclusion
Supplemental Beta-carotene (60-120 mg/day) is associated with an increase in all-cause mortality and cardiovascular death in patients at increased risk for lung cancer.
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Grade: II
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
What is the relationship between supplemental vitamin E, vitamin C or beta-carotene and all-cause mortality in adults?-
Conclusion
Supplementation with the antioxidants vitamin C, vitamin E and/or beta-carotene does not decrease, and in some cases may increase, all-cause mortality. Two meta-analyses of beta-carotene supplementation (1.2mg to 50mg) both reported increased mortality. Two of six meta-analyses of vitamin E supplementation (ranging from 16.5 IU to 5,000 IU) reported increased mortality. The one meta-analysis regarding supplementation with vitamin C (60mg to 2,000mg) reported no effect on mortality. Meta-analyses included 79 randomized controlled trials.
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Grade: II
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
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Conclusion