• Assessment
    What is the intake of sucralose in persons with diabetes and is this within the Acceptable Daily Intake (ADI) of non-nutritive sweeteners?
    • Conclusion

      To date, no studies were identified to evaluate the intake of sucralose in persons with diabetes and whether it is within ADI for non-nutritive sweeteners.

    • Grade: V
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
  • Intervention
    In adults, can sucralose be used to manage diabetes and glycemic response?
    • Conclusion

      Limited evidence from three controlled trials (Mezitis et al, 1996; Reyna et al, 2003; Grotz et al, 2003) showed little or no effects of sucralose on metabolic effects, including blood glucose in adults; however, the trials were of small size and used varying doses of sucralose for different lengths of time.

      Two trials (Mezitis et al, 1996; Reyna et al, 2003) found no difference in measures of glycemic response when sucralose was added to diets compared with control diets. One trial (Grotz et al, 2003) found decreased glycoslyated hemoglobin levels and fasting plasma glucose levels from baseline in adults with diabetes after consuming sucralose for three months. The sucralose group also had a statistically significant decrease in fasting plasma glucose from baseline as compared to the control group. 

      The 2009 update did not find new studies meeting the inclusion criteria for this question; the Nutritive and Non-nutritive Sweeteners Workgroup (2009) reviewed and accepted these studies identified by the Non-nutritive Sweeteners Workgroup (2006).

       

    • Grade: III
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
    In children, can sucralose be used to manage diabetes and glycemic response?
    • Conclusion

      To date, no studies were identified to evaluate the use of sucralose to manage diabetes and glycemic response in children.

    • Grade: V
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.