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Assessment
Are the calorie needs for cancer patients undergoing hematopoietic cell transplant different than the RDA?
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Conclusion
Two studies (one positive-quality longitudinal study and one positive-quality RCT) suggest that patients receiving HCT for hematologic malignancies require, on average, 35-40 kcal per kg per day to maintain nitrogen balance and body weight during the first month post-transplant. However, energy requirements may be higher during acute GVHD and for patients receiving > 75% of their total daily energy intake via PN. These studies evaluated patients receiving myeloablative allogeneic HCT, and energy needs may be different for patients receiving non-myeloablative and/or autologous HCT.
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Grade: II
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
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Search Plan and Results: HCT: Calories, Protein, Lipids, Nutritional Intake, EN/PN 2006
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Conclusion