DLM: Alcohol (2001)
Citation:
Study Design:
Class:
- Click here for explanation of classification scheme.
Quality Rating:
Research Purpose:
To summarize the current literature on wine intake and cardiovascular disease.
Inclusion Criteria:
Not described.
Exclusion Criteria:
Not described.
Description of Study Protocol:
- Only population based descriptive studies and cohort studies have been used to evaluate the effect of alcohol on CHD
- The majority of the studies were done in men.
Data Collection Summary:
Not described.
Description of Actual Data Sample:
Not described.
Summary of Results:
Possible benefits of alcohol use:
- More than 60 prospective studies suggest an inverse relationship between moderate alcohol consumption (one to two drinks per day) and CHD
- Most cohort studies do not support an association between type of alcoholic beverage and prevention of heart disease; a few have suggested that wine may be more beneficial than other alcohols
- One to two drinks per day increase HDL by ~12% on average. However, no clinical trials have been done to verify the effect of alcohol on HDL.
- Light to moderate consumption of any type of alcohol-containing beverage (60ml per day) appears to reduce platelet aggregation and provides an antithrombotic benefit similar to that of aspirin.
Possible adverse effects of alcohol use:
- From the Nurses Health Study consumption of more than 20g alcohol per day in women 30 to 55 years of age is associated with a linear increase in the incidence of HTN
- Intakes of more than 20g alcohol per day in men is also associated with HTN, but the relationship is less linear than in women
- Long term consumption of alcohol (more than 60g per day) increases an individuals's risk for all stroke subtypes
- Alcohol consumption can increase serum triglyceride and VLDL cholesterol
- Alcohol consumption can increase can exacerbate pancreatitis.
Author Conclusion:
- Moderate intake of alcoholic beverages (one to two drinks per day) is associated with a decreased risk of CHD in populations
- Without a large-scale, randomized, clinical end-point trial of wine intake, there is little current justification to recommend alcohol (or wine specifically) as a cardioprotective strategy
- The American Heart Association maintains its recommendations that alcohol use should be an item of discussion between physician and patient.
Funding Source:
Not-for-profit |
|
Reviewer Comments:
- Criteria for article inclusion was not described
- Search strategy was not described, nor was study quality assessed
- For the most part, gender of study participants was not described.
Quality Criteria Checklist: Review Articles
|
|||
Relevance Questions | |||
1. | Will the answer if true, have a direct bearing on the health of patients? | Yes | |
2. | Is the outcome or topic something that patients/clients/population groups would care about? | Yes | |
3. | Is the problem addressed in the review one that is relevant to dietetics practice? | Yes | |
4. | Will the information, if true, require a change in practice? | Yes | |
Validity Questions | |||
1. | Was the question for the review clearly focused and appropriate? | Yes | |
2. | Was the search strategy used to locate relevant studies comprehensive? Were the databases searched and the search termsused described? | No | |
3. | Were explicit methods used to select studies to include in the review? Were inclusion/exclusion criteria specified andappropriate? Wereselectionmethods unbiased? | No | |
4. | Was there an appraisal of the quality and validity of studies included in the review? Were appraisal methodsspecified,appropriate, andreproducible? | No | |
5. | Were specific treatments/interventions/exposures described? Were treatments similar enough to be combined? | No | |
6. | Was the outcome of interest clearly indicated? Were other potential harms and benefits considered? | Yes | |
7. | Were processes for data abstraction, synthesis, and analysis described? Were they applied consistently acrossstudies and groups? Was thereappropriate use of qualitative and/or quantitative synthesis? Was variation in findings among studies analyzed? Were heterogeneity issued considered? If data from studies were aggregated for meta-analysis, was the procedure described? | No | |
8. | Are the results clearly presented in narrative and/or quantitative terms? If summary statistics are used, are levels ofsignificance and/or confidence intervals included? | Yes | |
9. | Are conclusions supported by results with biases and limitations taken into consideration? Are limitations ofthe review identified anddiscussed? | No | |
10. | Was bias due to the review's funding or sponsorship unlikely? | Yes | |