NSCR: Quick and Easy Nutrition Screening Tools: Adult Patients in Acute and Ambulatory Care Settings (2009)
The purpose of the study was to test whether the Mini Nutrition Assessment-Short Form (MNA-SF) would have predicted the results supplied by the full Mini Nutrition Assessment.
- Ambulatory patients
- Over 60 years of age
- Scheduled for elective surgery or exploration under anesthesia
- Scheduled for surgery between January and October 1996
- Received and were assessed during anethesia consultation
- All questionnaire items recorded on full MNA.
- Patients who did not meet the inclusion criteria
- No other specific exclusion criteria listed.
Recruitment
- Database of MNA files
- Database consisted of MNA files from patients from the Centre Hopitalier Universitaire de Nimes, France (university hospital) and the Clinique Beausoleil, Montpellier, France (private surgical hospital)
- Every patient who met inclusion criteria between January and October 1996 was included in the study.
Design
- Full MNA questionnaire was applied to each patient during a previous study
- Patients had American Society of Anesthesiologists (ASA) score recorded to document overall clinical assessment during a previous study
- MNA-SF score was determined using six questions from full MNA database from the previous study
- Appetite loss or eating problem
- Recent weight loss
- House-bound
- Acute illness or stress
- Dementia or depression
- BMI <23kg/m2
- If MNA-SF score was greater than 12 then patient was not at risk and a full MNA would not have been required
- MNA-SF was assessed based on whether or not it would have identified patients at risk of malnutrition or with overt malnutrition as determined by the full MNA
- The performance of the MNA-SF was compared to the overall clinical assessment as determined by the ASA score.
Statistical Analysis
- Specificity
- Sensitivity
- Positve and negative predictive values (PPV, NPV)
- Likelihood ratio positive and negative (LRP, LRN)
- Odds ratio
- Chi-squared and non-parametric U-tests were used for comparison; signifcance was P<0.05
Timing of Measurements
- Data collected between January and October 1996
- Data collected during pre-surgery anesthesia consultation.
Dependent Variables
Score on MNA-SF.
Independent Variables
- Score on full MNA
- ASA score.
Initial N
- 408 completed MNA files
- 204 men
- 204 women.
Attrition (final N)
- 408 completed MNA files
- 204 men
- 204 women.
Age
- Median age is 72 years
- Range is 60-98 years.
Other relevant demographics
- 62.8% scheduled for general surgery
- 22.7% scheduled for orthopedic surgery
- 6.7% scheduled for endoscopies
- 7.9% scheduled for miscellaneous procedures
- 291 ASA one to two patients
- 117 ASA three to four patients.
Anthropometrics [median (range)]
- Height=165cm (134-186)
- Weight=68.5kg (34-114)
- BMI=25.2kg/m2 (12.8-40.4).
Location
- Centre Hospitalier Universitaire de Nimes, France (228 patients)
- Clinique Beausoleil, Montpellier, France (191 patients).
|
MNA Score Indicated: |
MNA Score Indicated: |
MNA Score Indicated: Normal |
|
---|---|---|---|---|
MNA-SF Positive |
28 patients |
85 patients |
31 patients |
144 (35.3%) |
MNA-SF Negative |
zero patients |
19 patients |
245 patients |
264 (64.7%) |
|
28 (6.9%) |
104 (25.5%) |
276 (67.6%) |
408 (100%) |
- MNA-SF for predicting absence of overt malnutrition (full MNA score less than 17):
- Sensitivity was 100% compared to full MNA
- Specificity was 69.5% compared to full MNA
- NPV was 100% and LRN was zero
- PPV was 19.4% and LRP was 3.28
- OR was infinite.
- MNA-SF for predicting absence of risk of undernutirtion (full MNA score less than 23.5):
- Sensitivity was 85.6% compared to full MNA
- Specificity was 88.8% compared to full MNA
- NPV was 92.8% and LRN was 0.16
- PPV was 78.5% and LRP was 7.64
- OR =47.75.
|
ASA Score One to Two |
ASA Score Three to Four |
|
MNA-SF Positive |
86 (29.6%) patients |
58 (49.6%) patients |
144 (35.3%) |
MNA-SF Negative |
205 (70.4%) patients |
59 (50.4%) patients |
264 (64.7%) |
|
291 (71.3%) |
117 (28.7%) |
408 (100%) |
- The MNA-SF scores were not able to predict the ASA scores
- The ASA scores were not able to predict the MNA-SF scores.
Other Findings
- Based on the MNA-SF results
- 31 patients would have been submitted to the full MNA and have been found without a nutritional problem
- 19 at-risk patients would not have received the full MNA.
- The MNA-SF would have correctly excluded 264 of 380 patients without severe malnutrition
- The MNA-SF was less efficient for excluding the presence of milder nutirtional risk
- Due to its simplicity, the MNA-SF should be used as the first step in the pre-operative nutritional assessment of older surgical patients.
Industry: |
|
- Ethnicity of the pariticpants was not identified
- Descriptive data for the patients was not separated by hospital
- Patients from the two hospitals were not analyzed separately
- No mention of whether or not informed consent was obtained from the patients
- No mention of whether or not the study received approval or review by an institutional review board.
Quality Criteria Checklist: Primary Research
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Relevance Questions | |||
1. | Would implementing the studied intervention or procedure (if found successful) result in improved outcomes for the patients/clients/population group? (Not Applicable for some epidemiological studies) | ??? | |
1. | Would implementing the studied intervention or procedure (if found successful) result in improved outcomes for the patients/clients/population group? (Not Applicable for some epidemiological studies) | ??? | |
2. | Did the authors study an outcome (dependent variable) or topic that the patients/clients/population group would care about? | No | |
2. | Did the authors study an outcome (dependent variable) or topic that the patients/clients/population group would care about? | No | |
3. | Is the focus of the intervention or procedure (independent variable) or topic of study a common issue of concern to dieteticspractice? | Yes | |
3. | Is the focus of the intervention or procedure (independent variable) or topic of study a common issue of concern to dieteticspractice? | Yes | |
4. | Is the intervention or procedure feasible? (NA for some epidemiological studies) | Yes | |
4. | Is the intervention or procedure feasible? (NA for some epidemiological studies) | Yes | |
Validity Questions | |||
1. | Was the research question clearly stated? | Yes | |
1. | Was the research question clearly stated? | Yes | |
1.1. | Was (were) the specific intervention(s) or procedure(s) [independent variable(s)] identified? | Yes | |
1.1. | Was (were) the specific intervention(s) or procedure(s) [independent variable(s)] identified? | Yes | |
1.2. | Was (were) the outcome(s) [dependent variable(s)] clearly indicated? | Yes | |
1.2. | Was (were) the outcome(s) [dependent variable(s)] clearly indicated? | Yes | |
1.3. | Were the target population and setting specified? | Yes | |
1.3. | Were the target population and setting specified? | Yes | |
2. | Was the selection of study subjects/patients free from bias? | Yes | |
2. | Was the selection of study subjects/patients free from bias? | Yes | |
2.1. | Were inclusion/exclusion criteria specified (e.g., risk, point in disease progression, diagnostic or prognosis criteria), and with sufficient detail and without omitting criteria critical to the study? | Yes | |
2.1. | Were inclusion/exclusion criteria specified (e.g., risk, point in disease progression, diagnostic or prognosis criteria), and with sufficient detail and without omitting criteria critical to the study? | Yes | |
2.2. | Were criteria applied equally to all study groups? | Yes | |
2.2. | Were criteria applied equally to all study groups? | Yes | |
2.3. | Were health, demographics, and other characteristics of subjects described? | Yes | |
2.3. | Were health, demographics, and other characteristics of subjects described? | Yes | |
2.4. | Were the subjects/patients a representative sample of the relevant population? | Yes | |
2.4. | Were the subjects/patients a representative sample of the relevant population? | Yes | |
3. | Were study groups comparable? | Yes | |
3. | Were study groups comparable? | Yes | |
3.1. | Was the method of assigning subjects/patients to groups described and unbiased? (Method of randomization identified if RCT) | Yes | |
3.1. | Was the method of assigning subjects/patients to groups described and unbiased? (Method of randomization identified if RCT) | Yes | |
3.2. | Were distribution of disease status, prognostic factors, and other factors (e.g., demographics) similar across study groups at baseline? | N/A | |
3.2. | Were distribution of disease status, prognostic factors, and other factors (e.g., demographics) similar across study groups at baseline? | N/A | |
3.3. | Were concurrent controls or comparisons used? (Concurrent preferred over historical control or comparison groups.) | No | |
3.3. | Were concurrent controls or comparisons used? (Concurrent preferred over historical control or comparison groups.) | No | |
3.4. | If cohort study or cross-sectional study, were groups comparable on important confounding factors and/or were preexisting differences accounted for by using appropriate adjustments in statistical analysis? | N/A | |
3.4. | If cohort study or cross-sectional study, were groups comparable on important confounding factors and/or were preexisting differences accounted for by using appropriate adjustments in statistical analysis? | N/A | |
3.5. | If case control study, were potential confounding factors comparable for cases and controls? (If case series or trial with subjects serving as own control, this criterion is not applicable.) | N/A | |
3.5. | If case control study, were potential confounding factors comparable for cases and controls? (If case series or trial with subjects serving as own control, this criterion is not applicable.) | N/A | |
3.6. | If diagnostic test, was there an independent blind comparison with an appropriate reference standard (e.g., "gold standard")? | ??? | |
3.6. | If diagnostic test, was there an independent blind comparison with an appropriate reference standard (e.g., "gold standard")? | ??? | |
4. | Was method of handling withdrawals described? | No | |
4. | Was method of handling withdrawals described? | No | |
4.1. | Were follow-up methods described and the same for all groups? | No | |
4.1. | Were follow-up methods described and the same for all groups? | No | |
4.2. | Was the number, characteristics of withdrawals (i.e., dropouts, lost to follow up, attrition rate) and/or response rate (cross-sectional studies) described for each group? (Follow up goal for a strong study is 80%.) | No | |
4.2. | Was the number, characteristics of withdrawals (i.e., dropouts, lost to follow up, attrition rate) and/or response rate (cross-sectional studies) described for each group? (Follow up goal for a strong study is 80%.) | No | |
4.3. | Were all enrolled subjects/patients (in the original sample) accounted for? | Yes | |
4.3. | Were all enrolled subjects/patients (in the original sample) accounted for? | Yes | |
4.4. | Were reasons for withdrawals similar across groups? | N/A | |
4.4. | Were reasons for withdrawals similar across groups? | N/A | |
4.5. | If diagnostic test, was decision to perform reference test not dependent on results of test under study? | Yes | |
4.5. | If diagnostic test, was decision to perform reference test not dependent on results of test under study? | Yes | |
5. | Was blinding used to prevent introduction of bias? | ??? | |
5. | Was blinding used to prevent introduction of bias? | ??? | |
5.1. | In intervention study, were subjects, clinicians/practitioners, and investigators blinded to treatment group, as appropriate? | ??? | |
5.1. | In intervention study, were subjects, clinicians/practitioners, and investigators blinded to treatment group, as appropriate? | ??? | |
5.2. | Were data collectors blinded for outcomes assessment? (If outcome is measured using an objective test, such as a lab value, this criterion is assumed to be met.) | ??? | |
5.2. | Were data collectors blinded for outcomes assessment? (If outcome is measured using an objective test, such as a lab value, this criterion is assumed to be met.) | ??? | |
5.3. | In cohort study or cross-sectional study, were measurements of outcomes and risk factors blinded? | N/A | |
5.3. | In cohort study or cross-sectional study, were measurements of outcomes and risk factors blinded? | N/A | |
5.4. | In case control study, was case definition explicit and case ascertainment not influenced by exposure status? | N/A | |
5.4. | In case control study, was case definition explicit and case ascertainment not influenced by exposure status? | N/A | |
5.5. | In diagnostic study, were test results blinded to patient history and other test results? | ??? | |
5.5. | In diagnostic study, were test results blinded to patient history and other test results? | ??? | |
6. | Were intervention/therapeutic regimens/exposure factor or procedure and any comparison(s) described in detail? Were interveningfactors described? | No | |
6. | Were intervention/therapeutic regimens/exposure factor or procedure and any comparison(s) described in detail? Were interveningfactors described? | No | |
6.1. | In RCT or other intervention trial, were protocols described for all regimens studied? | N/A | |
6.1. | In RCT or other intervention trial, were protocols described for all regimens studied? | N/A | |
6.2. | In observational study, were interventions, study settings, and clinicians/provider described? | N/A | |
6.2. | In observational study, were interventions, study settings, and clinicians/provider described? | N/A | |
6.3. | Was the intensity and duration of the intervention or exposure factor sufficient to produce a meaningful effect? | Yes | |
6.3. | Was the intensity and duration of the intervention or exposure factor sufficient to produce a meaningful effect? | Yes | |
6.4. | Was the amount of exposure and, if relevant, subject/patient compliance measured? | N/A | |
6.4. | Was the amount of exposure and, if relevant, subject/patient compliance measured? | N/A | |
6.5. | Were co-interventions (e.g., ancillary treatments, other therapies) described? | N/A | |
6.5. | Were co-interventions (e.g., ancillary treatments, other therapies) described? | N/A | |
6.6. | Were extra or unplanned treatments described? | No | |
6.6. | Were extra or unplanned treatments described? | No | |
6.7. | Was the information for 6.4, 6.5, and 6.6 assessed the same way for all groups? | Yes | |
6.7. | Was the information for 6.4, 6.5, and 6.6 assessed the same way for all groups? | Yes | |
6.8. | In diagnostic study, were details of test administration and replication sufficient? | Yes | |
6.8. | In diagnostic study, were details of test administration and replication sufficient? | Yes | |
7. | Were outcomes clearly defined and the measurements valid and reliable? | Yes | |
7. | Were outcomes clearly defined and the measurements valid and reliable? | Yes | |
7.1. | Were primary and secondary endpoints described and relevant to the question? | Yes | |
7.1. | Were primary and secondary endpoints described and relevant to the question? | Yes | |
7.2. | Were nutrition measures appropriate to question and outcomes of concern? | Yes | |
7.2. | Were nutrition measures appropriate to question and outcomes of concern? | Yes | |
7.3. | Was the period of follow-up long enough for important outcome(s) to occur? | Yes | |
7.3. | Was the period of follow-up long enough for important outcome(s) to occur? | Yes | |
7.4. | Were the observations and measurements based on standard, valid, and reliable data collection instruments/tests/procedures? | Yes | |
7.4. | Were the observations and measurements based on standard, valid, and reliable data collection instruments/tests/procedures? | Yes | |
7.5. | Was the measurement of effect at an appropriate level of precision? | Yes | |
7.5. | Was the measurement of effect at an appropriate level of precision? | Yes | |
7.6. | Were other factors accounted for (measured) that could affect outcomes? | No | |
7.6. | Were other factors accounted for (measured) that could affect outcomes? | No | |
7.7. | Were the measurements conducted consistently across groups? | Yes | |
7.7. | Were the measurements conducted consistently across groups? | Yes | |
8. | Was the statistical analysis appropriate for the study design and type of outcome indicators? | Yes | |
8. | Was the statistical analysis appropriate for the study design and type of outcome indicators? | Yes | |
8.1. | Were statistical analyses adequately described and the results reported appropriately? | Yes | |
8.1. | Were statistical analyses adequately described and the results reported appropriately? | Yes | |
8.2. | Were correct statistical tests used and assumptions of test not violated? | Yes | |
8.2. | Were correct statistical tests used and assumptions of test not violated? | Yes | |
8.3. | Were statistics reported with levels of significance and/or confidence intervals? | N/A | |
8.3. | Were statistics reported with levels of significance and/or confidence intervals? | N/A | |
8.4. | Was "intent to treat" analysis of outcomes done (and as appropriate, was there an analysis of outcomes for those maximally exposed or a dose-response analysis)? | No | |
8.4. | Was "intent to treat" analysis of outcomes done (and as appropriate, was there an analysis of outcomes for those maximally exposed or a dose-response analysis)? | No | |
8.5. | Were adequate adjustments made for effects of confounding factors that might have affected the outcomes (e.g., multivariate analyses)? | No | |
8.5. | Were adequate adjustments made for effects of confounding factors that might have affected the outcomes (e.g., multivariate analyses)? | No | |
8.6. | Was clinical significance as well as statistical significance reported? | No | |
8.6. | Was clinical significance as well as statistical significance reported? | No | |
8.7. | If negative findings, was a power calculation reported to address type 2 error? | N/A | |
8.7. | If negative findings, was a power calculation reported to address type 2 error? | N/A | |
9. | Are conclusions supported by results with biases and limitations taken into consideration? | Yes | |
9. | Are conclusions supported by results with biases and limitations taken into consideration? | Yes | |
9.1. | Is there a discussion of findings? | Yes | |
9.1. | Is there a discussion of findings? | Yes | |
9.2. | Are biases and study limitations identified and discussed? | Yes | |
9.2. | Are biases and study limitations identified and discussed? | Yes | |
10. | Is bias due to study's funding or sponsorship unlikely? | Yes | |
10. | Is bias due to study's funding or sponsorship unlikely? | Yes | |
10.1. | Were sources of funding and investigators' affiliations described? | Yes | |
10.1. | Were sources of funding and investigators' affiliations described? | Yes | |
10.2. | Was the study free from apparent conflict of interest? | Yes | |
10.2. | Was the study free from apparent conflict of interest? | Yes | |