• Intervention
    What are the effects of fish oil therapy on the outcomes of IgA nephropathy?
    • Conclusion

      Renal outcomes (proteinuria and rate of GFR decline) were inconsistent among patients with IgA nephropathy who received fish oil supplementation. One 4-year randomized controlled trial indicated a slower decline in renal function and decrease in proteinuria in patients with IgA nephropathy who received 6 grams of fish oil (1.43 grams EPA+DHA) per day in comparison to the control group.  Trials of 2 years in duration or less that prescribed 3-4 grams fish oil supplements (1.35-3.35 grams EPA+DHA) per day did not report a consistent significant effect on renal outcomes. In addition, a  meta-analysis of 5 earlier trials suggested similar results. Despite such findings, there were various positive effects on other study parameters (e.g., lipid profiles, homocysteine levels).

    • Grade: II
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
    What are the effects of fish oil therapy on the outcomes of renal transplant?
    • Conclusion

      There is insufficient evidence to support fish oil therapy to improve renal function and patient or graft survival for kidney transplant patients. Limited evidence shows potential benefit of fish oil in reducing oxidative stress and improving lipid profiles.

    • Grade: III
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.