HF: L-arginine (2007)
For the patient with heart failure, does L-arginine provide beneficial outcomes?
Four preliminary studies have found patients with heart failure may benefit from L-arginine, however the data is from small studies that used variable dosages and delivery techniques (IV vs. oral) with transient endpoints of variable clinical significance. Subjects in these studies were taking other medications for heart failure, including digoxin, diuretics, angiotensin-converting enzyme inhibitors and glyceryl trinitrate, though in three studies, the medications were discontinued prior to the study. Further research on the effect of L-arginine use in patients with heart failure is needed.
- Grade I means there is good evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited;
- Grade IV is Expert Opinion;
- Grade V is Not Assignable.
Evidence Summary: L-Arginine and heart failure outcomes
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Bednarz B, Jaxa-Chamiec T, Gebalska J, Herbaczynska-Cedro K, Ceremuzynski L. L-arginine supplementation prolongs exercise capacity in congestive heart failure. Kardiol Pol. 2004, Apr; 60 (4): 348-353.
- Kanaya Y, Nakamura M, Kobayashi N, Hiramori K. Effects of L-arginine on lower limb vasodilator reserve and exercise capacity in patients with chronic heart failure. Heart. 1999; 81: 512-517.
- Koifman B, Wollman Y, Bogomolny N, Chernichowsky T, Finkelstein A, Peer G, Scherez J, Blum M, Laniado S, Iaina A, Keren G. Improvement of cardiac performance by intravenous infusion of L-arginine in patients with moderate congestive heart failure. J Am Coll Cardiol. 1995 Nov 1; 26 (5): 1,251-1,256.
- Prior DL, Jennings GLR, Chin-Dusting JPF. Transient improvement of acetylcholine responses after short-term oral L-argininen in forearms of human heart failure. J Cardiovascular Pharmacology. 2000; 36: 3-37.
Search Plan and Results: Arginine and Heart Failure 2004