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Intervention
Is there a relationship between supplementation of antioxidant vitamin E, which may interact with radiation therapy treatment, tolerance of radiation therapy treatment and late-effects of radiation therapy treatment in patients with chronic radiation-induced fibrosis resulting from breast cancer treatment?
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Conclusion
Research neither supports nor refutes the use of oral vitamin E supplementation for improved tolerance to or outcome of treatment in breast cancer patients undergoing radiation therapy. However, some evidence shows that oral supplementation of vitamin E may be beneficial in treating late-effects of radiation therapy treatment. One positive quality RCT found no effectiveness of oral vitamin E on the treatment of chronic RIF resulting from breast cancer treatment as measured by perometer. A study of neutral quality found an effect, but the fibrosis measurement methodology was not validated. Larger PRCTs with validated measures of radiation therapy effect are needed.
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Grade: III
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
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Search Plan and Results: Antioxidants and Radiation Therapy 2006
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Conclusion