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Assessment
Is there a dose response relationship of the soy protein and/or isoflavone effects on cholesterol levels?
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Conclusion
A significant dose response relationship has not been established between level of soy protein and/or isoflavones in the diet needed to achieve significant decreases in total and LDL cholesterol.
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Grade: III
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
What daily amounts of soy protein (as supplement) are well tolerated?-
Conclusion
Diets containing up to 30 grams of soy protein (as supplements) per day were well tolerated.
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Grade: II
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
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Conclusion
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Intervention
Does a person's initial cholesterol levels affect the impact of soy protein and/or isoflavones?
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Conclusion
Effect of soy protein and/or isoflavones may vary based on initial cholesterol levels
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Grade: III
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
What does the evidence indicate is the relationship between intake of soy protein and serum total cholesterol, LDL-cholesterol, and triglycerides levels?-
Conclusion
Studies varied greatly in their estimation of the effect of diets low in saturated fat and cholesterol containing ~26-50 g of soy protein either as food or as a soy supplement, with 0-165 mg of isoflavones. Studies of individuals with normal and elevated cholesterol (total cholesterol >200mg/dL) and individuals with diabetes varied showing:
- no effect on total cholesterol up to 20% lower serum total cholesterol
- no effect on TG up to 22% lower
- small effect (4%) up to 24% lower LDL-cholesterol.
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Grade: II
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
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Conclusion