• Basic Research
    In an adult population taking an over-the-counter anti-coagulant (ASA, St. John’s Wart, Vitamin K, ) what is the impact of doses of Vitamin E alone greater than the RDA (15mg)?
    • Conclusion

      To date, no studies are available to determine if there is an impact from doses of Vitamin E alone greater than the RDA (15mg) in the adult population taking an over-the-counter anti-coagulant (ASA, St. John’s Wart, Vitamin K, etc ).

    • Grade: V
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
    In an adult population taking a prescription anti-coagulant [warfarin, enoxaparin (Lovanox), dabigatran (Pradaxa), rivaroxaban (Xarelto), apixaban (Eliquis)] what is the impact of doses of Vitamin E alone greater than the RDA (15mg)?
    • Conclusion

      There is limited evidence (with much heterogeneity between the studies) to determine the impact of supplemental vitamin E (in dosages from 100 IU to 1,200 IU) in an adult population on chronic anti-coagulant therapy.
       

    • Grade: III
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.