Cystic Fibrosis (CF) Systematic Review (2018-19)

Cystic Fibrosis (CF) Systematic Review (2018-19)

Cystic Fibrosis Systematic Review

Systematic Review

The aim of the systematic review supporting the evidence-based guideline was to examine the current evidence regarding optimal nutrition screening and assessment methods and the relationships between MNT, dietary intake and nutrition-related outcomes for people with cystic fibrosis (CF).

Key Findings: The evidence examining the relationship between MNT delivered by and RDN and nutrition-related outcomes in CF was sparse. Observational evidence described that MNT did improve anthropometric outcomes in pediatric participants with CF when delivered at least quarterly. However, evidence quality was very low for all other nutrition-related outcomes, including pulmonary function.

While controlled trials provide the highest-quality evidence, it was clear from a prior scoping review that evidence regarding the relationships between dietary intake and nutrition-related outcomes was sparse and, thus, observational evidence was also examined in this systematic review. Though the workgroup searched for a wide variety of dietary exposures including specific food groups, dietary patterns and macronutrient distribution, only 17 observational studies met inclusion criteria, and most had a cross-sectional study design. This limited evidence described no clear relationships between dietary intake and nutrition-related outcomes for individuals with CF.

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