Nutritional Genomics

NG: Effect on Health Outcomes (2018-19)

• Intervention
  In adults, what is the effect of incorporating results of genetic testing into nutrition counseling and care, compared to an alternative intervention or control group, on anxiety and depression scores?

  • Conclusion

    In cognitively healthy adults, when both the intervention and comparison groups received ApoE genotype disclosure in relation to Alzheimer’s disease risk, there was no significant difference in anxiety or depression scores when participants received additional information on the relation of ApoE genotype to coronary artery disease and lifestyle strategies to reduce the frequency of coronary artery disease.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In adults, what is the effect of incorporating results of genetic testing into nutrition counselling and care, compared to an alternative intervention or control group, on anxiety and depression scores?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Christensen K, Roberts J, Whitehouse P, Royal C, Obisesan T, Cupples L, Vernarelli J, Bhatt D, Linnenbringer E, Butson M, Fasaye G, Uhlmann W, Hiraki S, Wang N, Cook-Deegan R, Green R. Disclosing pleiotropic effects during genetic risk assessment for Alzheimer disease: a randomized trial. Annals of Internal Medicine 2016; 164:155-63
  • Search Plan and Results: NG: Incorporating Results of Genetic Testing into Nutrition Counseling or Care (2019)
     
  In adults, what is the effect of incorporating results of genetic testing into nutrition counseling and care, compared to an alternative intervention or control group, on fatty liver Hamaguchi score?

  • Conclusion

    In adults with non-alcoholic fatty liver disease (NAFLD), there was no significant difference in fatty liver Hamaguchi scores when results of genetic testing were incorporated into nutrition counseling and care as compared to counseling or care that did not incorporate genetic results.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In adults, what is the effect of incorporating results of genetic testing into nutrition counselling and care, compared to an alternative intervention or control group, on fatty liver Hamaguchi score?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Stachowska E, Ryterska K, Maciejewska D, Banaszczak M, Milkiewicz P, Milkiewicz M, Gutowska I, Ossowski P, Kaczorowska M, Jamiol-Milc D, Sabinicz A, Napierala M, Wadolowska L, Raszeja-Wyszomirska J. Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR). International Journal of Molecular Sciences 2016; 17:
  • Search Plan and Results: NG: Incorporating Results of Genetic Testing into Nutrition Counseling or Care (2019)
     
  In adults, what is the effect of incorporating results of genetic testing into nutrition counseling and care, compared to an alternative intervention or control group, on INTERHEART Risk Score (IHRS)?

  • Conclusion

    In healthy adults of South-Asian descent, when both the intervention and comparison groups received genetic information related to myocardial infarction (MI) risk, there was no significant difference in INTERHEART risk score when participants received more intensive, personalized nutrition counseling.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In adults, what is the effect of incorporating results of genetic testing into nutrition counselling and care, compared to an alternative intervention or control group, on INTERHEART Risk Score (IHRS)?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Samaan Z, Schulze K, Middleton C, Irvine J,J oseph P, Mente A, Shah B, Pare G, Desai D, Anand S. South Asian heart risk assessment (SAHARA): randomized controlled trial design and pilot study. JMIR Research Protocols 2013; 2:e33
  • Search Plan and Results: NG: Incorporating Results of Genetic Testing into Nutrition Counseling or Care (2019)
     
  In adults, what is the effect of incorporating results of genetic testing into nutrition counseling and care, compared to an alternative intervention or control group, on Quality of Life and mortality?

  • Conclusion

    No articles examining the effect of incorporating results of genetic testing in nutrition counseling and care, compared to an alternative intervention or control group, on Quality of Life or mortality in adults met inclusion criteria for this systematic review.

  • Grade: V
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  In children, what is the effect of incorporating results of genetic testing into nutrition counseling and care, compared to an alternative intervention or control group, on hard outcomes?

  • Conclusion

    No articles examining the effect of incorporating results of genetic testing in nutrition counseling and care, compared to an alternative intervention or control group, on hard outcomes in children met inclusion criteria for this systematic review.

  • Grade: V
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.