CD: Gluten-free Diet (2021)
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Intervention
In patients with celiac disease, what are the effects of gluten-free diet (GFD), in comparison to a control or adherence to a gluten-free diet, on anthropometrics?
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Conclusion
A gluten-free diet (GFD) and adherence to a GFD may affect maintenance and achievement of a normal BMI or weight. (Low or GRADE III)
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Grade: Low (C)
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
-
Evidence Summary: In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on anthropometrics?
- Detail
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Worksheets
- Cheng J, Brar P, Lee A, Green P. Body mass index in celiac disease: beneficial effect of a gluten-free diet. Journal of Clinical Gastroenterology 2010; 44:267-271
- Comba A, Çaltepe G, Yüce Ö, Erena E, Kalayc A. Effects of age of diagnosis and dietary compliance on growth parameters of patients with celiac disease. Archivos Argentinos de Pediatria 2018; 116:248-255
- Forchielli M, Fernicola P, Diani L, Scrivo B, Salfi N, Pessina A, Lima M, Conti V, Pession A. Gluten-Free Diet and Lipid Profile in Children With Celiac Disease: Comparison With General Population Standards. Journal of Pediatric Gastroenterology and Nutrition 2015; 61:224-229
- Heyman R, Guggenbuhl P, Corbel A, Bridoux-Henno L, Tourtelier Y, Balençon-Morival M, de Kerdanet M, Dabadie A. Effect of a gluten-free diet on bone mineral density in children with celiac disease. Gastroenterologie Clinique et Biologique 2009; 33:109-114
- Hopman E, von Blomberg M, Batstra M, Morreau H, Dekker F, Koning F, Lamers C, Mearin M. Gluten tolerance in adult patients with celiac disease 20 years after diagnosis?. European Journal of Gastroenterology & Hepatology 2008; 20:423-429
- Kabbani T, Goldberg A, Kelly C, Pallav K, Tariq S, Peer A, Hansen J, Dennis M, Leffler D. Body mass index and the risk of obesity in coeliac disease treated with the gluten-free diet. Alimentary Pharmacology & Therapeutics 2012; 35:723-729
- Karadas U, Eliacik K, Baran M, Kanik A, Ozdemir N, Ince OT, Bakiler AR. The subclinical effect of celiac disease on the heart and the effect of gluten-free diet on cardiac functions. Turkish Journal of Pediatrics 2016; 58:241-245
- Kautto E, Rydén P, Ivarsson A, Olsson C, Norström F, Högberg L, Carlsson A, Hagfors L, Hörnell A. What happens to food choices when a gluten-free diet is required? A prospective longitudinal population-based study among Swedish adolescent with coeliac disease and their peers. Journal of Nutritional Science 2014; 3:e2
- Korpimäki S, Kaukinen K, Collin P, Haapala A, Holm P, Laurila K, Kurppa K, Saavalainen P, Haimila K, Partanen J, Mäki M, Lähdeaho M. Gluten-sensitive hypertransaminasemia in celiac disease: an infrequent and often subclinical finding. American Journal of Gastroenterology 2011; 106:1689-1696
- Kurppa K, Paavola A, Collin P, Sievänen H, Laurila K, Huhtala H, Saavalainen P, Mäki M, Kaukinen K. Benefits of a gluten-free diet for asymptomatic patients with serologic markers of celiac disease. Gastroenterology 2014; 147:610-617.e1
- Laine O, Pitkänen K, Lindfors K, Huhtala H, Niemelä O, Collin P, Kurppa K, Kaukinen K. Elevated serum antiphospholipid antibodies in adults with celiac disease. Digestive and Liver Disease 2018; 50:457-461
- Pludowski P, Karczmarewicz E, Socha J, Matusik H, Syczewska M, Lorenc R. Skeletal and muscular status in juveniles with GFD treated clinical and newly diagnosed atypical celiac disease--preliminary data. Journal of Clinical Densitometry 2007; 10:76-85
- Rajpoot P, Sharma A, Harikrishnan S, Baruah B, Ahuja V, Makharia G. Adherence to gluten-free diet and barriers to adherence in patients with celiac disease. Indian Journal of Gastroenterology 2015; 34:380-386
- Sun S, Puttha R, Ghezaiel S, Skae M, Cooper C, Amin R. The effect of biopsy-positive silent coeliac disease and treatment with a gluten-free diet on growth and glycaemic control in children with Type 1 diabetes. Diabetic Medicine : A Journal of the British Diabetic Association 2009; 26:1250-1254
- Valerio G, Spadaro R, Iafusco D, Lombardi F, Del Puente A, Esposito A, De Terlizzi F, Prisco F, Troncone R, Franzese A. The influence of gluten free diet on quantitative ultrasound of proximal phalanxes in children and adolescents with type 1 diabetes mellitus and celiac disease. Bone 2008; 43:322-326
- Wagner G, Berger G, Sinnreich U, Grylli V, Schober E, Huber W, Karwautz A. Quality of life in adolescents with treated coeliac disease: influence of compliance and age at diagnosis. Journal of Pediatric Gastroenterology and Nutrition 2008; 47:555-561
- Wiech P, Chmiel Z, Bazalinski D, Salacinska I, Bartosiewicz A, Mazur A, Korczowski B, Binkowska-Bury, M, Dabrowski M. The Relationship between Body Composition and aGluten Free Diet in Children with Celiac Disease. Nutrients 2018; 10:1817
- Detail
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Search Plan and Results: CD: Gluten Free Diet 2020
In patients with celiac disease, what are the effects of gluten-free diet (GFD), in comparison to a control or adherence to a gluten-free diet, on indicators of bone metabolism?-
Conclusion
The effect of a gluten-free diet (GFD) on bone mineral density is inconclusive; however, adherence to a GFD has a positive effect on bone mineral density in children with celiac disease. (Low or GRADE III)
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Grade: Low (C)
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
-
Evidence Summary: In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on indicators of bone metabolism?
- Detail
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Worksheets
- Blazina S, Bratanic N, Campa A, Blagus R, Orel R. Bone mineral density and importance of strict gluten-free diet in children and adolescents with celiac disease. Bone 2010; 47:598-603
- Heyman R, Guggenbuhl P, Corbel A, Bridoux-Henno L, Tourtelier Y, Balençon-Morival M, de Kerdanet M, Dabadie A. Effect of a gluten-free diet on bone mineral density in children with celiac disease. Gastroenterologie Clinique et Biologique 2009; 33:109-114
- Hopman E, von Blomberg M, Batstra M, Morreau H, Dekker F, Koning F, Lamers C, Mearin M. Gluten tolerance in adult patients with celiac disease 20 years after diagnosis?. European Journal of Gastroenterology & Hepatology 2008; 20:423-429
- Kahramanoglu Aksoy E, Yener Akpinar M, Pirincci Sapmaz F, Dogan O, Uzman M, Nazligul Y. Thymic stromal lymphopoietin levels are increased in patients with celiac disease. Bosnian Journal of Basic Medical Sciences 2019; 19:282-287
- Kurppa K, Paavola A, Collin P, Sievänen H, Laurila K, Huhtala H, Saavalainen P, Mäki M, Kaukinen K. Benefits of a gluten-free diet for asymptomatic patients with serologic markers of celiac disease. Gastroenterology 2014; 147:610-617.e1
- Margoni D, Chouliaras G, Duscas G, Voskaki I, Voutsas N, Papadopoulou A, Panayiotou J, Roma E. Bone health in children with celiac disease assessed by dual x-ray absorptiometry: effect of gluten-free diet and predictive value of serum biochemical indices. Journal of Pediatric Gastroenterology and Nutrition 2012; 54:680-684
- Pludowski P, Karczmarewicz E, Socha J, Matusik H, Syczewska M, Lorenc R. Skeletal and muscular status in juveniles with GFD treated clinical and newly diagnosed atypical celiac disease--preliminary data. Journal of Clinical Densitometry 2007; 10:76-85
- Szymczak J, Bohdanowicz-Pawlak A, Waszczuk E, Jakubowska J. Low bone mineral density in adult patients with coeliac disease. Endokrynologia Polska 2012; 63:270-276
- Usta M, Urganci N. Does gluten-free diet protect children with celiac disease from low bone density?. Iranian Journal of Pediatrics 2014; 24:429-434
- Valerio G, Spadaro R, Iafusco D, Lombardi F, Del Puente A, Esposito A, De Terlizzi F, Prisco F, Troncone R, Franzese A. The influence of gluten free diet on quantitative ultrasound of proximal phalanxes in children and adolescents with type 1 diabetes mellitus and celiac disease. Bone 2008; 43:322-326
- Detail
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Search Plan and Results: CD: Gluten Free Diet 2020
In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on nutrition-related laboratory measures?-
Conclusion
A gluten-free diet (GFD) and GFD adherence may not have an effect on select nutrition-related laboratory measures, except for ferritin and zinc, which were negatively impacted by GFD non-adherence. (Low or GRADE III)
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Grade: Low (C)
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
-
Evidence Summary: In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on nutrition-related laboratory measures?
- Detail
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Worksheets
- Ferretti G, Bacchetti T, Saturni L, Manzella N, Candelaresi C, Benedetti A, Di Sario A. Lipid peroxidation and paraoxonase-1 activity in celiac disease. Journal of Lipids 2012; 2012:587479
- Forchielli M, Fernicola P, Diani L, Scrivo B, Salfi N, Pessina A, Lima M, Conti V, Pession A. Gluten-Free Diet and Lipid Profile in Children With Celiac Disease: Comparison With General Population Standards. Journal of Pediatric Gastroenterology and Nutrition 2015; 61:224-229
- Högberg L, Danielsson L, Jarleman S, Sundqvist T, Stenhammar L. Serum zinc in small children with coeliac disease. Acta Paediatrica 2009; 98:343-345
- Kahramanoglu Aksoy E, Yener Akpinar M, Pirincci Sapmaz F, Dogan O, Uzman M, Nazligul Y. Thymic stromal lymphopoietin levels are increased in patients with celiac disease. Bosnian Journal of Basic Medical Sciences 2019; 19:282-287
- Karadas U, Eliacik K, Baran M, Kanik A, Ozdemir N, Ince OT, Bakiler AR. The subclinical effect of celiac disease on the heart and the effect of gluten-free diet on cardiac functions. Turkish Journal of Pediatrics 2016; 58:241-245
- Korpimäki S, Kaukinen K, Collin P, Haapala A, Holm P, Laurila K, Kurppa K, Saavalainen P, Haimila K, Partanen J, Mäki M, Lähdeaho M. Gluten-sensitive hypertransaminasemia in celiac disease: an infrequent and often subclinical finding. American Journal of Gastroenterology 2011; 106:1689-1696
- Kurppa K, Paavola A, Collin P, Sievänen H, Laurila K, Huhtala H, Saavalainen P, Mäki M, Kaukinen K. Benefits of a gluten-free diet for asymptomatic patients with serologic markers of celiac disease. Gastroenterology 2014; 147:610-617.e1
- Laine O, Pitkänen K, Lindfors K, Huhtala H, Niemelä O, Collin P, Kurppa K, Kaukinen K. Elevated serum antiphospholipid antibodies in adults with celiac disease. Digestive and Liver Disease 2018; 50:457-461
- Rajpoot P, Sharma A, Harikrishnan S, Baruah B, Ahuja V, Makharia G. Adherence to gluten-free diet and barriers to adherence in patients with celiac disease. Indian Journal of Gastroenterology 2015; 34:380-386
- Sun S, Puttha R, Ghezaiel S, Skae M, Cooper C, Amin R. The effect of biopsy-positive silent coeliac disease and treatment with a gluten-free diet on growth and glycaemic control in children with Type 1 diabetes. Diabetic Medicine : A Journal of the British Diabetic Association 2009; 26:1250-1254
- Valerio G, Spadaro R, Iafusco D, Lombardi F, Del Puente A, Esposito A, De Terlizzi F, Prisco F, Troncone R, Franzese A. The influence of gluten free diet on quantitative ultrasound of proximal phalanxes in children and adolescents with type 1 diabetes mellitus and celiac disease. Bone 2008; 43:322-326
- Detail
-
Search Plan and Results: CD: Gluten Free Diet 2020
In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on indicators of gastrointestinal health and gastrointestinal symptoms?-
Conclusion
A gluten-free diet (GFD) may result in an improvement of indicators of gastrointestinal health and gastrointestinal symptoms among patients with celiac disease; however, there is limited current evidence to suggest the same for GFD adherence. (Low or GRADE III)
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Grade: Low (C)
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
-
Evidence Summary: In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on indicators of gastrointestinal health and gastrointestinal symptoms?
- Detail
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Worksheets
- Balamtekin N, Demir H, Baysoy G, Uslu N, Orhan D, Akcoren Z, Ozen H, Gurakan F, Saltik-Temizel IN, Yuce A. Fecal calprotectin concentration is increased in children with celiac disease: relation with histopathological findings. Turkish Journal of Gastroenterology 2012; 23:503-508
- Barratt S, Leeds J, Sanders D. Factors influencing the type, timing and severity of symptomatic responses to dietary gluten in patients with biopsy-proven coeliac disease. Journal of Gastrointestinal and Liver Diseases 2013; 22:391-396
- Bassotti G, Villanacci V, Mazzocchi A, Mariano M, Incardona P, Clerici C, Morelli A. Antroduodenojejunal motor activity in untreated and treated celiac disease patients. Journal of Gastroenterology and Hepatology 2008; 23:e23-28
- Casellas F, Rodrigo L, Vivancos J, Riestra S, Pantiga C, Baudet J, Junquera F, Diví V, Abadia C, Papo M, Gelabert J, Malagelada J. Factors that impact health-related quality of life in adults with celiac disease: a multicenter study. World Journal of Gastroenterology 2008; 14:46-52
- Catassi C, Fabiani E, Iacono G, D'Agate C, Francavilla R, Biagi F, Volta U, Accomando S, Picarelli A, De Vitis I, Pianelli G, Gesuita R, Carle F, Mandolesi A, Bearzi I, Fasano A. A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease. American Journal of Clinical Nutrition 2007; 85:160-166
- Collado M, Donat E, Ribes-Koninckx C, Calabuig M, Sanz Y. Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease. Journal of Clinical Pathology 2009; 62:264-269
- De Palma G, Nadal I, Medina M, Donat E, Ribes-Koninckx C, Calabuig M, Sanz Y. Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children. BMC Microbiology 2010; 10:63
- Ferretti G, Bacchetti T, Saturni L, Manzella N, Candelaresi C, Benedetti A, Di Sario A. Lipid peroxidation and paraoxonase-1 activity in celiac disease. Journal of Lipids 2012; 2012:587479
- Hopman E, von Blomberg M, Batstra M, Morreau H, Dekker F, Koning F, Lamers C, Mearin M. Gluten tolerance in adult patients with celiac disease 20 years after diagnosis?. European Journal of Gastroenterology & Hepatology 2008; 20:423-429
- Korpimäki S, Kaukinen K, Collin P, Haapala A, Holm P, Laurila K, Kurppa K, Saavalainen P, Haimila K, Partanen J, Mäki M, Lähdeaho M. Gluten-sensitive hypertransaminasemia in celiac disease: an infrequent and often subclinical finding. American Journal of Gastroenterology 2011; 106:1689-1696
- Koskinen O, Collin P, Lindfors K, Laurila K, Mäki M, Kaukinen K. Usefulness of small-bowel mucosal transglutaminase-2 specific autoantibody deposits in the diagnosis and follow-up of celiac disease. Journal of Clinical Gastroenterology 2010; 44:483-488
- Kurppa K, Paavola A, Collin P, Sievänen H, Laurila K, Huhtala H, Saavalainen P, Mäki M, Kaukinen K. Benefits of a gluten-free diet for asymptomatic patients with serologic markers of celiac disease. Gastroenterology 2014; 147:610-617.e1
- Laine O, Pitkänen K, Lindfors K, Huhtala H, Niemelä O, Collin P, Kurppa K, Kaukinen K. Elevated serum antiphospholipid antibodies in adults with celiac disease. Digestive and Liver Disease 2018; 50:457-461
- Norsa L, Branchi F, Bravo M, Ferretti F, Roncoroni L, Somalvico F, Conte D, Bardella M, Fabiano S, Barigelletti G, Elli L. Celiac Disease 30 Years After Diagnosis: Struggling With Gluten-free Adherence or Gaining Gluten Tolerance?. Journal of Pediatric Gastroenterology and Nutrition 2018; 67:361-366
- Rajpoot P, Sharma A, Harikrishnan S, Baruah B, Ahuja V, Makharia G. Adherence to gluten-free diet and barriers to adherence in patients with celiac disease. Indian Journal of Gastroenterology 2015; 34:380-386
- Usai P, Manca R, Cuomo R, Lai M, Boi M. Effect of gluten-free diet and co-morbidity of irritable bowel syndrome-type symptoms on health-related quality of life in adult coeliac patients. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2007; 39:824-828
- van Koppen E, Schweizer J, Csizmadia C, Krom Y, Hylkema H, van Geel A, Koopman H, Verloove-Vanhorick S, Mearin M. Long-term health and quality-of-life consequences of mass screening for childhood celiac disease: a 10-year follow-up study. Pediatrics 2009; 123:e582-588
- Detail
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Search Plan and Results: CD: Gluten Free Diet 2020
In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on dietary intake?-
Conclusion
A gluten-free diet (GFD) in comparison to a control may have a positive effect on dietary intake quality among patients with celiac disease, but the positive effect was not seen with varying adherence levels to a GFD. (Low or GRADE III)
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Grade: Low (C)
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
-
Evidence Summary: In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on dietary intake?
- Detail
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Worksheets
- Blazina S, Bratanic N, Campa A, Blagus R, Orel R. Bone mineral density and importance of strict gluten-free diet in children and adolescents with celiac disease. Bone 2010; 47:598-603
- Forchielli M, Fernicola P, Diani L, Scrivo B, Salfi N, Pessina A, Lima M, Conti V, Pession A. Gluten-Free Diet and Lipid Profile in Children With Celiac Disease: Comparison With General Population Standards. Journal of Pediatric Gastroenterology and Nutrition 2015; 61:224-229
- Kautto E, Rydén P, Ivarsson A, Olsson C, Norström F, Högberg L, Carlsson A, Hagfors L, Hörnell A. What happens to food choices when a gluten-free diet is required? A prospective longitudinal population-based study among Swedish adolescent with coeliac disease and their peers. Journal of Nutritional Science 2014; 3:e2
- Valerio G, Spadaro R, Iafusco D, Lombardi F, Del Puente A, Esposito A, De Terlizzi F, Prisco F, Troncone R, Franzese A. The influence of gluten free diet on quantitative ultrasound of proximal phalanxes in children and adolescents with type 1 diabetes mellitus and celiac disease. Bone 2008; 43:322-326
- Detail
-
Search Plan and Results: CD: Gluten Free Diet 2020
In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on celiac disease-related antibodies, inflammatory and immunological indicators?-
Conclusion
A gluten-free diet (GFD) and adherence to a GFD are associated with improved celiac disease-related antibodies, inflammatory and immunological indicators (Low or GRADE III).
-
Grade: Low (C)
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
-
Evidence Summary: In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on celiac disease-related antibodies, inflammatory and immunological indicators?
- Detail
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Worksheets
- Catassi C, Fabiani E, Iacono G, D'Agate C, Francavilla R, Biagi F, Volta U, Accomando S, Picarelli A, De Vitis I, Pianelli G, Gesuita R, Carle F, Mandolesi A, Bearzi I, Fasano A. A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease. American Journal of Clinical Nutrition 2007; 85:160-166
- Collado M, Donat E, Ribes-Koninckx C, Calabuig M, Sanz Y. Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease. Journal of Clinical Pathology 2009; 62:264-269
- Ferretti G, Bacchetti T, Saturni L, Manzella N, Candelaresi C, Benedetti A, Di Sario A. Lipid peroxidation and paraoxonase-1 activity in celiac disease. Journal of Lipids 2012; 2012:587479
- Hopman E, von Blomberg M, Batstra M, Morreau H, Dekker F, Koning F, Lamers C, Mearin M. Gluten tolerance in adult patients with celiac disease 20 years after diagnosis?. European Journal of Gastroenterology & Hepatology 2008; 20:423-429
- Ioannou H, Fotoulaki M, Pavlitou A, Efstratiou I, Augoustides-Savvopoulou P. Plasma citrulline levels in paediatric patients with celiac disease and the effect of a gluten-free diet. European Journal of Gastroenterology & Hepatology 2011; 23:245-249
- Kahramanoglu Aksoy E, Yener Akpinar M, Pirincci Sapmaz F, Dogan O, Uzman M, Nazligul Y. Thymic stromal lymphopoietin levels are increased in patients with celiac disease. Bosnian Journal of Basic Medical Sciences 2019; 19:282-287
- Koskinen O, Collin P, Lindfors K, Laurila K, Mäki M, Kaukinen K. Usefulness of small-bowel mucosal transglutaminase-2 specific autoantibody deposits in the diagnosis and follow-up of celiac disease. Journal of Clinical Gastroenterology 2010; 44:483-488
- Kurppa K, Paavola A, Collin P, Sievänen H, Laurila K, Huhtala H, Saavalainen P, Mäki M, Kaukinen K. Benefits of a gluten-free diet for asymptomatic patients with serologic markers of celiac disease. Gastroenterology 2014; 147:610-617.e1
- Laine O, Pitkänen K, Lindfors K, Huhtala H, Niemelä O, Collin P, Kurppa K, Kaukinen K. Elevated serum antiphospholipid antibodies in adults with celiac disease. Digestive and Liver Disease 2018; 50:457-461
- Wagner G, Berger G, Sinnreich U, Grylli V, Schober E, Huber W, Karwautz A. Quality of life in adolescents with treated coeliac disease: influence of compliance and age at diagnosis. Journal of Pediatric Gastroenterology and Nutrition 2008; 47:555-561
- Detail
-
Search Plan and Results: CD: Gluten Free Diet 2020
In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on indicators of quality of life?-
Conclusion
The evidence suggests that a gluten-free diet (GFD) and greater adherence to a GFD may improve quality of life among patients with celiac disease, but the evidence is unclear (Very low or GRADE III).
-
Grade: Very Low (D)
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
-
Evidence Summary: In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on indicators of quality of life?
- Detail
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Worksheets
- Barratt S, Leeds J, Sanders D. Quality of life in Coeliac Disease is determined by perceived degree of difficulty adhering to a gluten-free diet, not the level of dietary adherence ultimately achieved. Journal of Gastrointestinal and Liver Diseases 2011; 20:241-245
- Casellas F, Rodrigo L, Vivancos J, Riestra S, Pantiga C, Baudet J, Junquera F, Diví V, Abadia C, Papo M, Gelabert J, Malagelada J. Factors that impact health-related quality of life in adults with celiac disease: a multicenter study. World Journal of Gastroenterology 2008; 14:46-52
- Casellas F, Rodrigo L, Lucendo A, Fernández-Bañares F, Molina-Infante J, Vivas S, Rosinach M, Dueñas C, López-Vivancos J. Benefit on health-related quality of life of adherence to gluten-free diet in adult patients with celiac disease. Revista Espanola de Enfermedades Digestivas 2015; 107:196-201
- Chauhan J, Kumar P, Dutta A, Basu S, Kumar A. Assessment of dietary compliance to gluten free diet and psychosocial problems in Indian children with celiac disease (CD). Indian Journal of Pediatrics 2010; 77:649-654
- Esenyel S, Unal F, Vural P. Depression and anxiety in child and adolescents with follow-up celiac disease and in their families. Turkish Journal of Gastroenterology 2014; 25:381-385
- Hopman E, Koopman H, Wit J, Mearin M. Dietary compliance and health-related quality of life in patients with coeliac disease. European Journal of Gastroenterology & Hepatology 2009; 21:1056-1061
- Kurppa K, Paavola A, Collin P, Sievänen H, Laurila K, Huhtala H, Saavalainen P, Mäki M, Kaukinen K. Benefits of a gluten-free diet for asymptomatic patients with serologic markers of celiac disease. Gastroenterology 2014; 147:610-617.e1
- Rajpoot P, Sharma A, Harikrishnan S, Baruah B, Ahuja V, Makharia G. Adherence to gluten-free diet and barriers to adherence in patients with celiac disease. Indian Journal of Gastroenterology 2015; 34:380-386
- Usai P, Manca R, Cuomo R, Lai M, Boi M. Effect of gluten-free diet and co-morbidity of irritable bowel syndrome-type symptoms on health-related quality of life in adult coeliac patients. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2007; 39:824-828
- van Hees N, Van der Does W, Giltay E. Coeliac disease, diet adherence and depressive symptoms. Journal of Psychosomatic Research 2013; 74:155-160
- van Koppen E, Schweizer J, Csizmadia C, Krom Y, Hylkema H, van Geel A, Koopman H, Verloove-Vanhorick S, Mearin M. Long-term health and quality-of-life consequences of mass screening for childhood celiac disease: a 10-year follow-up study. Pediatrics 2009; 123:e582-588
- Wagner G, Berger G, Sinnreich U, Grylli V, Schober E, Huber W, Karwautz A. Quality of life in adolescents with treated coeliac disease: influence of compliance and age at diagnosis. Journal of Pediatric Gastroenterology and Nutrition 2008; 47:555-561
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Search Plan and Results: CD: Gluten Free Diet 2020
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Conclusion