CRDA: Other Outcomes (2023)
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Intervention
In adults with overweight or obesity and no other established disease, what is the effect of carbohydrate (CHO) restriction compared to higher CHO diets on adverse events?
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Conclusion
Evidence is unclear regarding intake of a low- or moderate-carbohydrate (CHO) diet compared to a higher CHO intake on adverse events in adults with overweight or obesity and no other established disease.
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Grade: Very Low (D)
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
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Evidence Summary: In adults with overweight or obesity and no other established disease, what is the effect of carbohydrate (CHO) restriction compared to higher CHO diets on adverse events?
- Detail
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Worksheets
- Haslam R, Bezzina A, Herbert J, Spratt N, Rollo M, Collins C. Can Ketogenic Diet Therapy Improve Migraine Frequency, Severity and Duration?. Healthcare (Basel, Switzerland) 2021; 9:
- Mateo-Gallego R, Marco-Benedí V, Perez-Calahorra S, Bea A, Baila-Rueda L, Lamiquiz-Moneo I, de Castro-Orós I, Cenarro A,Civeira F. Energy-restricted, high-protein diets more effectively impact cardiometabolic profile in overweight and obese women than lower-protein diets. Clinical Nutrition 2017; 36:371-379
- Raben A, Vestentoft P, Brand-Miller J, Jalo E, Drummen M, Simpson L, Martinez J, Handjieva-Darlenska T, Stratton G, Huttunen-Lenz M, Lam T, Sundvall J, Muirhead R, Poppitt S, Ritz C, Pietiläinen K, Westerterp-Plantenga M, Taylor M, Navas-Carretero S, Handjiev S, McNarry M, Hansen S, Råman L,Brodie S, Silvestre M, Adam T, Macdonald I, San-Cristobal R, Boyadjieva N, Mackintosh K, Schlicht W, Liu A, Larsen T, Fogelholm M. The PREVIEW intervention study: Results from a 3-year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes. Diabetes, Obesity & Metabolism 2021; 23:324-337
- Detail
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Search Plan and Results: CRDA: Overweight or Obesity and No Other Established Disease 2023
In adults with overweight or obesity and no other established disease, what is the effect of carbohydrate (CHO) restriction compared to higher CHO diets on cognitive function?-
Conclusion
Intake of a moderate-carbohydrate (CHO) diet compared to a slightly higher moderate-CHO intake (↑2.9% of total daily energy intake) may have no effect on total age-related cognitive function score in adults with overweight or obesity and no other established disease; however the evidence is uncertain.
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Grade: Very Low (D)
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
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Evidence Summary: In adults with overweight or obesity and no other established disease, what is the effect of carbohydrate (CHO) restriction compared to higher CHO diets on cognitive function?
- Detail
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Worksheets
- Detail
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Search Plan and Results: CRDA: Overweight or Obesity and No Other Established Disease 2023
In adults with overweight or obesity and no other established disease, what is the effect of carbohydrate (CHO) restriction compared to higher CHO diets on quality of life?-
Conclusion
Intake of a low-carbohydrate (CHO) diet compared to a moderate CHO intake may improve migraine-specific quality of life in adults with overweight or obesity and no other established disease; however the evidence is uncertain.
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Grade: Very Low (D)
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
- Evidence Summary: In adults with overweight or obesity and no other established disease, what is the effect of carbohydrate (CHO) restriction compared to higher CHO diets on quality of life?
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Search Plan and Results: CRDA: Overweight or Obesity and No Other Established Disease 2023
In adults with overweight or obesity and no other established disease, what is the effect of carbohydrate (CHO) restriction compared to higher CHO diets on type 2 diabetes mellitus incidence?-
Conclusion
Evidence suggests that intake of a moderate-carbohydrate (CHO) diet compared to a slightly higher moderate-CHO intake (↑3.6% of total daily energy intake) may have effect on incidence of type 2 diabetes mellitus after three years in adults with overweight or obesity and no other established disease.
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Grade: Low (C)
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
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Evidence Summary: In adults with overweight or obesity and no other established disease, what is the effect of carbohydrate (CHO) restriction compared to higher CHO diets on type 2 diabetes mellitus incidence?
- Detail
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Worksheets
- Detail
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Search Plan and Results: CRDA: Overweight or Obesity and No Other Established Disease 2023
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Conclusion