One neutral quality RCT found that while prophylactic PN preserved nutritional status and lean body mass better than oral diet in well-nourished breast cancer patients undergoing auto-HCT, there were no differences found in LOS or survival between the two groups.   The researchers concluded that well-nourished breast cancer patients who have no major complications or prolonged poor oral intake will probably not benefit from PN while undergoing auto-HCT.  Because of its expense and risk for infectious complications, PN should be used in appropriate breast cancer patients only. 

• Grade I means there is Good/Strong evidence supporting the statement;
• Grade II is Fair;
• Grade III is Limited/Weak;
• Grade IV is Expert Opinion Only;
• Grade V is Not Assignable.
• High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
• Moderate (B) means we are moderately confident in the effect estimate;
• Low (C) means our confidence in the effect estimate is limited;
• Very Low (D) means we have very little confidence in the effect estimate.
• Ungraded means a grade is not assignable.