Menard J, Payette H, et al. 2005

16293781

Efficacy of intensive multitherapy for patients with type 2 diabetes mellitus: a randomized controlled trial.

Ménard J, Payette H, Baillargeon J, Maheux P, Lepage S, Tessier D, Ardilouze J

Canadian Medical Association Journal

2005

173

12

1457-1466

Randomized Controlled Trial

Some concerns

Patients with type 2 diabetes mellitus (1985 World Health Organization criteria) and receiving any therapy regimen, between 30 and 70 years of age and with hemoglobin A1c concentrations of 8% or greater were eligible to participate in the study.

We excluded patients with hypoglycemia unawareness, severe or uncontrolled cardiovascular disease (defined as a cardiovascular event within the last year), dyspnea higher than class II,17 proteinuria greater than 300 mg/day, proliferative retinopathy (defined as growth of new blood vessels on the retina and posterior surface of the vitreous), chronic foot ulrs or wounds, or psychiatric disease or cognitive impairment interfering with treatment compliance. We also excluded patients who were unable to perform the exercise program or detect sensation with the use of a 10-g monofilament.

To determine whether a 1-year intensive multitherapy program resulted in greater goal attainment than usual care among patients with poorly controlled type 2 diabetes mellitus.

Not reported

Centre Hospitalier Universitaire de Sherbrooke, Quebec, Canada

Industry, University/Hospital

This work was supported by the Clinical Research Centre of the Centre Hospitaler Universitaire de Sherbrooke and by grants from Brystol-Myers Squibb and the Quebec Diabetes Association.