T1DM: Vitamin D Supplementation (2023)
Author and Year:
Shih E, Mittelman S, et al. 2014
PubMed ID:
Article Title:
Effects of vitamin D repletion on glycemic control and inflammatory cytokines in adolescents with type 1 diabetes.
Authors:
Shih E, Mittelman S, Pitukcheewanont P, Azen C, Monzavi R
Journal:
Pediatric Diabetes
Year of publication:
2014
Volume:
17
Issue:
1
Page numbers:
36-43
Study Design:
Randomized Crossover Trial
Risk of Bias Assessment Rating:
Low risk
Inclusion Criteria:
13-21 yr of age (at least Tanner stage 4 for males or post-menarcheal for females); type 1 diabetes for at least a year; HbA1c between 7 and 9% (53 to 75 mmol/mol); on insulin pump therapy; all subjects had adequate renal (serum creatinine <1.5 mg/dL in males and <1.2 mg/dL in females) and hepatic (AST and ALT <2.5 times the upper limit of normal) function; vitamin D deficiency (defined by a 25-OH vitamin D level ?30 ng/mL on initial screening laboratory test).
Exclusion Criteria:
Subjects taking any medication that could interfere with vitamin D synthesis or metabolism (including but not limited to Orlistat, Phenobarbital, Dilantin, and anti-tuberculosis drugs).Subjects taking any medication other than insulin that could alter blood glucose levels (including but not limited to
glucocorticoids). Subjects with known or suspected malabsorption.
Research Purpose:
To examine whether or not treating Vitamin D deficiency in adolescents with type 1 diabetes would improve glycemia and reduce inflammatory markers.
Blinding efforts:
Not reported
Study Location:
Endocrinology Cliic at Children's Hospital Los Angeles
Source(s) of Funding:
University/Hospital
Please specify names of funders:
Grant #UL1TR000130: Children’s Hospital Los Angeles from the National Center for Advancing Translational Sciences (NCATS) at the National
Institute of Health and Saban Research Institute at Children’s Hospital Los Angeles