Malta D, Arcand J, Ravindran A, et al. 2016

27581475

Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system.

Malta D, Arcand J, Ravindran A, Floras V, Allard J, Newton G

American Journal of Clinical Nutrition

2016

104

4

990-994

Randomized Controlled Trial

Some concerns

Ages 18-25; stable without hospitalizations in the 3 months before study entry. All recruited participants were receiving hypertension treatment with >/=1 ACEi or ARB, and all had a potassium intake <2500 mg/d, as estimated by a 24-hour recall at the time of recruitment.

Exclusion criteria included treatment with insulin, loop and potassium-sparing diuretics, a serum potassium concentration >5.0 mmol/L, and a serum creatinine concentration >130 mmol/L.

The purpose of this study was to assess the effect of increasing dietary potassium on serum potassium concentration in hypertensive individuals with normal renal function treated with an ACEi or ARB. We hypothesized that an increase in dietary potassium would not provoke hyperkalemia in this population despite treatment with either an ACEi or ARB.

See Risk of Bias.

Canada

Not reported