The prevalence of hypertension and hyperlipidemia with risk for cardiovascular disease, coronary artery disease, and left ventricular hypertrophy is higher in chronic kidney disease compared to the general population. Aggressive treatment of hypertension with a goal of <135/85 mm Hg without proteinuria and <125/75 mm Hg with proteinuria >1g protein/24 hours with medications and restriction of dietary sodium to 1 to 3 g per day will slow the progression of kidney disease and reduce the risk of cardiovascular disease. Serum potassium should be monitored because of the effect of some antihypertensive agents on potassium excretion.