Nutritional Genomics

Nutritional Genomics

Welcome to the Nutritional Genomics Project

The next frontier in nutrition care is precision nutrition, which aims to personalize nutrition recommendations based not only on diet history and phenotype, but also on additional molecular factors, such as an individual’s genotype, microbiome, proteome and metabolome. The field of nutritional genomics is one aspect of precision nutrition and describes how genotype affects metabolism, how diet affects the genome, and how the genome and diet interact to affect disease risk. Nutritional genomics was highlighted as the future of nutrition in a recent National Academy of Sciences workshop.

In 2014, the Academy of Nutrition and Dietetics published a Position Paper and Statement regarding the use of nutritional genomics in nutrition practice: “It is the position of the Academy of Nutrition and Dietetics that nutritional genomics provides insight into how diet and genotype interactions affect phenotype. The practical application of nutritional genomics for complex chronic disease is an emerging science and the use of nutrigenetic testing to provide dietary advice is not ready for routine dietetics practice. Registered dietitian nutritionists need basic competency in genetics as a foundation for understanding nutritional genomics; proficiency requires advanced knowledge and skills.”

Currently, there are no evidence-based guidelines or systematic reviews focusing on the effect of utilizing nutritional genomics in nutrition practice. A recent systematic review and meta-analysis by the Cochrane collaboration focused on the effect of communicating genetic risk for disease, but was not limited to nutrition-focused studies and did not examine the effect of gene disclosure associated with nutrient metabolism. The Academy will conduct a systematic review on this important topic.

Use the tab titled Scoping Review in the left navigation bar for information on the review. The systematic review is in progress and expected to be complete in January 2020. 

Updated: 3/4/2019