Glycemic control and effective treatment of hypertension and proteinuria has been shown to be effective in delaying the onset and progression of chronic kidney disease in patients with both diabetes type 1 and 2. The Diabetes Complications and Control Trial in patients with type 1 diabetes mellitus and the United Kingdom Prospective Diabetes Study in patients with Type 2 diabetes mellitus demonstrated that intensive treatment resulting in near normal A1C reduced the incidence of microabuminuria and diabetic nephropathy.