EAL

Intervention
Can non-nutritive sweeteners (saccharin, aspartame, acesulfame-K, sucralose, neotame) be used to manage diabetes and glycemic response in people with diabetes?
- Conclusion
  In a limited number of studies, NNS had no effect on changes in blood lipid profiles and glycemic response in adults with diabetes. No studies in children were identified.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
Basic Research
What is the intake of non-nutritive sweeteners (saccharin, aspartame, acesulfame-K, sucralose, neotame) in persons with diabetes, and is this within the Acceptable Daily Intake (ADI) of non-nutritive sweeteners?
- Conclusion
  In a limited number of studies conducted outside the United States, children and adults with diabetes were found to have higher intakes of NNS as compared to controls, which did not exceed the Acceptable Daily Intake (ADI) in most instances. The exception was Swedish children’s intakes of acesulfame-K and saccharin, which was greater than the ADI when “worst case” estimates were used. Further studies are needed in both children and adults, specifically in the United States.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.