12 studies were reviewed to evaluate lifestyle interventions for the treatment of hyperlipidemia in people with HIV infection. Two studies demonstrate that protease inhibitor therapy is associated with hyperlipidemia. Three studies report that other lifestyle factors are associated with hyperlipidemia, such as exercise and the consumption of fat, fiber and alcohol. Research on several lifestyle modification interventions for the treatment of hyperlipidemia in people with HIV infection reports improvements in serum lipid profile.