Limited research in humans, from peer-reviewed journals, did not find an association between adverse effects and the intake of sucralose in the general population. No data from longitudinal cohort studies were available for review.

The Nutritive and Non-nutritive Sweeteners Workgroup (2009-10) reviewed and accepted the studies (Grice and Goldsmith, 2000; Weihrauch et al, 2004) identified by the Non-nutritive Sweeteners Workgroup (2006) and found one additional article (Grotz and Munro, 2009) meeting the inclusion criteria for the update of this question.

• Grade I means there is Good/Strong evidence supporting the statement;
• Grade II is Fair;
• Grade III is Limited/Weak;
• Grade IV is Expert Opinion Only;
• Grade V is Not Assignable.
• High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
• Moderate (B) means we are moderately confident in the effect estimate;
• Low (C) means our confidence in the effect estimate is limited;
• Very Low (D) means we have very little confidence in the effect estimate.
• Ungraded means a grade is not assignable.