(ONC) Enteral vs Parenteral Nutrition (2025)

Intervention
In adults with hematologic cancers, what is the association between enteral nutrition compared to parenteral nutrition and weight?
- Conclusion
  In adults with hematologic cancers, the association between enteral nutrition compared to parenteral nutrition and weight is uncertain secondary to very serious concerns for risk of bias and imprecision.
- Grade: Very Low (D)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults with hematologic cancers, what is the association between enteral nutrition compared to parenteral nutrition and weight?
  - Detail
  - Worksheets
    
    Guièze R, Lemal R, Cabrespine A, Hermet E, Tournilhac O, Combal C, Bay J, Bouteloup C. Enteral versus parenteral nutritional support in allogeneic haematopoietic stem-cell transplantation. Clinical Nutrition (Edinburgh, Scotland) 2014; 33:533-538
    
    Kuypers J, Simmance N, Quach H, Hastie K, Kiss N. Nutrition support use and clinical outcomes in patients with multiple myeloma undergoing autologous stem cell transplant. Supportive Care in Cancer 2022; 30:9341-9350
- Search Plan and Results: ONC: Nutrition Support for Hematologic Cancers (2025)
In adults with hematologic cancers, what is the association between enteral nutrition compared to parenteral nutrition and length of stay?
- Conclusion
  In adults with hematologic cancers, the association between enteral nutrition compared to parenteral nutrition and length of stay is uncertain secondary to very serious concerns for risk of bias and serious imprecision.
- Grade: Very Low (D)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults with hematologic cancers, what is the association between enteral nutrition compared to parenteral nutrition and length of stay?
  - Detail
  - Worksheets
    
    Guièze R, Lemal R, Cabrespine A, Hermet E, Tournilhac O, Combal C, Bay J, Bouteloup C. Enteral versus parenteral nutritional support in allogeneic haematopoietic stem-cell transplantation. Clinical Nutrition (Edinburgh, Scotland) 2014; 33:533-538
    
    Kuypers J, Simmance N, Quach H, Hastie K, Kiss N. Nutrition support use and clinical outcomes in patients with multiple myeloma undergoing autologous stem cell transplant. Supportive Care in Cancer 2022; 30:9341-9350
    
    Seguy D, Duhamel A, Rejeb M, Gomez E, Buhl N, Bruno B, Cortot A, Yakoub-Agha I. Better outcome of patients undergoing enteral tube feeding after myeloablative conditioning for allogeneic stem cell transplantation. Transplantation 2012; 94:287-294
    
    Sheean P, Braunschweig C, Rich E, 2004. The incidence of hyperglycemia in hematopoietic stem cell transplant recipients receiving total parenteral nutrition: a pilot study. Journal of the American Dietetic Association 2004; 104:1352-1360
    
    Sheean P, Kilkus J, Liu D, Maciejewski J, Braunschweig C. Incident hyperglycemia, parenteral nutrition administration and adverse outcomes in patients with myeloma admitted for initial auto-SCT. Bone Marrow Transplantation 2013; 48:1117-1122
- Search Plan and Results: ONC: Nutrition Support for Hematologic Cancers (2025)
In adults with hematologic cancers, what is the association between enteral nutrition compared to parenteral nutrition and readmissions?
- Conclusion
  In adults with hematologic cancers, the association between enteral nutrition compared to parenteral nutrition and hospital readmissions is uncertain secondary to serious risk of bias and very serious imprecision.
- Grade: Very Low (D)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults with hematologic cancers, what is the association between enteral nutrition compared to parenteral nutrition and readmissions?
  - Detail
  - Worksheets
    
    Seguy D, Duhamel A, Rejeb M, Gomez E, Buhl N, Bruno B, Cortot A, Yakoub-Agha I. Better outcome of patients undergoing enteral tube feeding after myeloablative conditioning for allogeneic stem cell transplantation. Transplantation 2012; 94:287-294
- Search Plan and Results: ONC: Nutrition Support for Hematologic Cancers (2025)