One small RCT of neutral quality of 29 hospitalized patients found that nutritional care by an RD resulted in positive nutrition outcomes for patients receiving chemotherapy for acute lymphocytic and nonlymphocytic leukemia. Daily contact for assessment, education and motivation by an RD was effective in increasing body weight in the intervention group earlier and more often than in the control group (33.8% vs. 13.2%; 48.7% vs. 18.3% depending on treatment protocol).  The researchers found that nutrition intake was highly correlated with body weight status.  Mean daily energy intake of 23.3 ± 11.4 kcals/kg/day was associated with weight loss; 30.9 ± 13.1 kcals/kg/day was associated with stable weight; and 39.3 ± 12.2 kcals/kg/day was associated with weight gain (P < 0.0001).  A significant correlation was found between nutritional intake and tumor-therapy side effects (e.g., anorexia and fatigue) (P-values <0.01).

• Grade I means there is Good/Strong evidence supporting the statement;
• Grade II is Fair;
• Grade III is Limited/Weak;
• Grade IV is Expert Opinion Only;
• Grade V is Not Assignable.
• High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
• Moderate (B) means we are moderately confident in the effect estimate;
• Low (C) means our confidence in the effect estimate is limited;
• Very Low (D) means we have very little confidence in the effect estimate.
• Ungraded means a grade is not assignable.