EAL

Assessment
Do administration or changes in chemical use of alcohol have an acute effect on resting metabolic rate (RMR)?
- Conclusion
  
  10/19/04
  
  Two small studies of moderate quality (one in healthy males and one in healthy females, ages 21 to 41 years) report individual RMR increases of 1.1 - 13.6% over 95 minutesa fter ingestion of alcohol in healthy men (Weststrate, Wunnick, et al, 1990) and mean RMR increases of 9.0% have been recorded 90-10 minutes post-ingestion in women (Klesges RC, Mealer CZ, et al, 1994). In men, mean RMR increases of 4-6 % over 95 min or 124-287 kcal/24 hr, following 20-23 grams alcohol (140-251 kcals) consumption. These changes in RMR correspond with significant (P>0.05) decreases of 8-9% in respiratory quotient. No data are available to indicate duration of the effect of alcohol on RMR
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What effect does alcohol consumption have on energy expenditure?
Do administration or changes in chemical use of alcohol have a chronic effect on resting metabolic rate (RMR)?
- Conclusion
  
  10/19/04
  
  In one study of neutral quality rating, middle-aged alcoholics (mean age 42 y), the RMR was elevated (26%) due to chronic alcohol intake but decreased to levels similar to that of non-alcoholic controls within 14 days of abstention.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What effect does alcohol consumption have on energy expenditure?
Do administration or changes in chemical use of alcohol have an effect on resting metabolic rate (RMR) when alcohol is consumed with food?
- Conclusion
  
  10/19/04
  
  No effect is consistently supported in diet-induced thermogenesis when alcohol is administered with food.
- Grade: II
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What effect does alcohol consumption have on energy expenditure?