This Academy member benefit temporarily has been made public to allow all practitioners access to content that may assist in patient care during the national pandemic response. Click here for information on joining the Academy. 

Nutritive and Non-Nutritive Sweeteners

NNNS: Adverse Effects

Non-nutritive sweeteners and adverse effects 
Background: From time to time, questions arise about the safety of non-nutritive sweeteners particularly in regard to cancer, seizures, pregnancy and other toxicities. The FDA has approved the use of non-nutritive sweeteners and they are considered to be safe.  These FDA data are part of the pre-market assessment, are not published in peer reviewed journals and are not part of the Academy evidence analyzed for this EAL project. However, the Academy has provided you with a link to the U.S. Food and Drug Administration (FDA) Center for Food Safety and Applied Nutrition website.  
External Links:
  • FDA Click here to go to the "Redbook 2000: Toxicological Principles for the Safety Assessment of Food Ingredients" from the U.S. Food and Drug Administration (FDA) Center for Food Safety and Applied Nutrition website.
  • NCI Click here to go to the "National Cancer Institute Fact Sheet" regarding artificial sweeteners and cancer on the NCI website.
Note:  Only non-nutritive sweeteners approved by the FDA and considered to be safe for human consumption are included in the NNS evidence analysis project. These include: acesulfame-K, aspartame, neotame, saccharin, and sucrolose