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Nutritive and Non-Nutritive Sweeteners

NNNS: Adverse Effects (2011)

Adverse effects of neotame

Note:  Only non-nutritive sweeteners approved by the FDA and considered to be safe for human consumption are included in the N&NNS evidence analysis project. These include: acesulfame-K, aspartame, neotame, saccharin, stevia, and sucrolose.  Learn more.  

Non-nutritive sweeteners and FDA

ADA does not evaluate safety; however we do summarize the human subject research published in peer-reviewed journals regarding adverse effects.

  • Assessment
    What is the evidence from human subjects research that neotame consumption is associated with adverse effects in the general population?
    • Conclusion

      To date, no studies from human subject research in peer-reviewed literature were identified to evaluate adverse effects of neotame consumption in the general population.



    • Grade: V
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
    • Search Plan and Results: Neotame 2009