NNNS: Adverse Effects (2011)
Adverse effects of Sucralose
Note: Only non-nutritive sweeteners approved by the FDA and considered to be safe for human consumption are included in the N&NNS evidence analysis project. These include: acesulfame-K, aspartame, neotame, saccharin, stevia, and sucrolose. Learn more.
ADA does not evaluate safety; however we do summarize the human subject research published in peer-reviewed journals regarding adverse effects.
What is the evidence from human subjects research that sucralose consumption is associated with adverse effects in the general population?
Limited research in humans, from peer-reviewed journals, did not find an association between adverse effects and the intake of sucralose in the general population. No data from longitudinal cohort studies were available for review.
The Nutritive and Non-nutritive Sweeteners Workgroup (2009-10) reviewed and accepted the studies (Grice and Goldsmith, 2000; Weihrauch et al, 2004) identified by the Non-nutritive Sweeteners Workgroup (2006) and found one additional article (Grotz and Munro, 2009) meeting the inclusion criteria for the update of this question.
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
Evidence Summary: What is the evidence from human subjects research that sucralose consumption is associated with adverse effects in the general population?
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Grice HC, Goldsmith LA. Sucralose--an overview of the toxicity data. Food Chem Toxicol. 2000; 38, suppl. 2:S1-6. Review. No abstract available.
- Grotz VL, Munro IC. An overview of the safety of sucralose. Regulatory Toxicology and Pharmacology. 2009; 55: 1-5.
- Weihrauch MR, Diehl V. Artificial sweeteners-do they bear a carcinogenic risk? Annals of Oncology, 2004, 15: 1,460-1,465.
Search Plan and Results: Sucralose - 2009