NNNS: Adverse Effects (2011)
Adverse effects of Saccharin
Note: Only non-nutritive sweeteners approved by the FDA and considered to be safe for human consumption are included in the N&NNS evidence analysis project. These include: acesulfame-K, aspartame, neotame, saccharin, stevia, and sucrolose. Learn more.
ADA does not evaluate safety; however we do summarize the human subject research published in peer-reviewed journals regarding adverse effects.
What is the evidence from human subjects research that saccharin consumption is associated with adverse effects in the general population?
Limited research in humans, from peer-reviewed journals, did not find an association between adverse effects and the intake of saccharin in the general population. No data from longitudinal cohort studies were available for review.
The 2009 update did not find new studies meeting the inclusion criteria for this question; the Nutritive and Non-nutritive Sweeteners Workgroup (2009) reviewed and accepted the studies (Sommer et al 2004, Weihrauch and Diehl 2004, and Jensen and Kamby 1982) identified by the Non-nutritive Sweeteners Workgroup (2006).
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
Evidence Summary: What is the evidence from human subjects research that saccharin consumption is associated with adverse effects in the general population?
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Jenson OM, Kamby C. Intrauterine exposure to saccharin and risk of bladder cancer in man. Int J Cancer. 1982; 29: 507-509.
- Sommer F, et al. Lifestyle issues and genitourinary tumours. World J Urol. 2004 Feb; 21 (6): 402-413. Epub 2003 Dec 12. Review.
- Weihrauch MR, Diehl V. Artificial sweeteners-do they bear a carcinogenic risk? Annals of Oncology, 2004, 15: 1,460-1,465.
Search Plan and Results: Saccharin 2009