NNNS: Diabetes and Glycemic Response (2011)

NNNS: Diabetes and Glycemic Response (2011)

  • Assessment
    In adults with diabetes, what is the intake of saccharin and is this within the Acceptable Daily Intake (ADI) of non-nutritive sweeteners?
    • Conclusion

      To date, no studies were identified to evaluate the intake of saccharin in adults with diabetes and if it is within the ADI of non-nutritive sweeteners.

    • Grade: V
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
    In children with diabetes, what is the intake of saccharin, and is this within the Acceptable Daily Intake (ADI) of non-nutritive sweeteners?
    • Conclusion

      In one study conducted outside the United States, children with diabetes were found to have higher intakes of non-nutritive sweeteners, including saccharin, as compared to controls, which did not exceed the Acceptable Daily Intake (ADI). 

      The 2009 update did not find new studies meeting the inclusion criteria for this question; the Nutritive and Non-nutritive Sweeteners Workgroup (2009) reviewed and accepted the studies identified by the Non-nutritive Sweeteners Workgroup (2006).
    • Grade: III
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
  • Intervention
    In adults, can saccharin be used to manage diabetes and glycemic response?
    • Conclusion

      In a limited number of human studies, saccharin had no effect on changes in lipid profiles and glycemic response in adults with diabetes.

      The Nutritive and Non-nutritive Sweeteners Workgroup (2009) reviewed and accepted the studies identified by the Non-nutritive Sweeteners Workgroup (2006) and found one additional article (Skokan et al, 2007) meeting the inclusion criteria for the update of this question.

       


       
    • Grade: III
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
    In children, can saccharin be used to manage diabetes and glycemic response?
    • Conclusion

      To date, no studies were identified to evaluate the use of saccharin to manage diabetes and glycemic response in children.
       
       

    • Grade: V
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.