Wound Care

WC: Inflammation (2011)

The National Pressure Ulcer Advisory Panel (NPUAP) and the European Pressure Ulcer Advisory Panel (EPUAP) recently published evidence-based guidelines. Their methods met both Academy and AGREE (Appraisal of Guidelines for Research and Evaluation) criteria. The Academy Wound Care Expert Workgroup decided to formulate nutrition practice questions that were not addressed by the NPUAP-EPUAP Nutrition Guidelines for pressure ulcers. 

Inflammation and Wound Care

  • Assessment
    Do supplemental arginine, glutamine, cysteine, glycine or n-3 fatty acids reduce inflammation and thus improve wound healing?
    • Conclusion

      No studies were found that investigated whether supplemental arginine, glutamine, cysteine, glycine or n-3 fatty acids reduce inflammation and thus improve wound healing.

      Click here to view the full Introduction to the Wound Care evidence analysis project.

    • Grade: V
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
    • Search Plan and Results: WC: Macronutrient Composition, Inflammatory Process and Wound Healing 2011
       
    Does macronutrient composition of the diet (fat, sugar, protein) affect the inflammatory process and delay wound-healing in adults with a pressure ulcer?
    • Conclusion

      No studies were found that investigated whether macronutrient composition of the diet (fat, sugar, protein) affects the inflammatory process and delays wound-healing in adults with a pressure ulcer.

      Click here to view the full Introduction to the Wound Care evidence analysis project.

    • Grade: V
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
    • Search Plan and Results: WC: Macronutrient Composition, Inflammatory Process and Wound Healing 2011
       
    Should screening for pro-inflammatory conditions be included as part of nutrition assessment for adults with pressure ulcers?
    • Conclusion

      No studies were found that investigated whether screening for pro-inflammatory conditions should be included as part of nutrition assessment for adults with pressure ulcers.

      Click here to view the full Introduction to the Wound Care evidence analysis project.

    • Grade: V
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
    • Search Plan and Results: WC: Macronutrient Composition, Inflammatory Process and Wound Healing 2011
       
    What pharmacologic interventions may exacerbate inflammation and delay wound-healing in patients with pressure ulcers?
    • Conclusion

      No studies were found that investigated pharmacologic interventions that may exacerbate inflammation and delay wound-healing in patients with pressure ulcers.

      Click here to view the full Introduction to the Wound Care evidence analysis project.

    • Grade: V
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
    • Search Plan and Results: WC: Macronutrient Composition, Inflammatory Process and Wound Healing 2011