There is fair evidence that linoleic acid (LA) status is inversely associated with risk of type 2 diabetes mellitus (DM). Limited studies have shown an inverse relationship between LA status and risk factors for DM including insulin resistance, metabolic syndrome, inflammation, nerve function/neuropathy, and the liver enzyme, ALT, as a marker of liver fat.   

• Grade I means there is Good/Strong evidence supporting the statement;
• Grade II is Fair;
• Grade III is Limited/Weak;
• Grade IV is Expert Opinion Only;
• Grade V is Not Assignable.
• High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
• Moderate (B) means we are moderately confident in the effect estimate;
• Low (C) means our confidence in the effect estimate is limited;
• Very Low (D) means we have very little confidence in the effect estimate.
• Ungraded means a grade is not assignable.