NA: Sodium and Blood Pressure Response Table (2010)
|
|
NORMOTENSION
<120/80
|
PREHYPERTENSION
120-139 SBP and/or 80-89 DBP
|
HYPERTENSION
>140/90
|
|||||||
|
Author, year
|
Blood Pressure (mmHg) |
Na+ Change
|
Final Na Level Achieved
|
BP response
|
Na+ Change
|
Final Na Level Achieved
|
BP Response
|
Na+ Change
|
Final Na Level Achieved
|
BP Response
|
|
Appel, 2001
|
<145/85 |
N/A
|
N/A
|
N/A
|
N/A
|
N/A
|
N/A
|
↓ of -40mmol/L UNa (0.9g)
|
Level not specified
|
-4.3/-2.0
|
|
Bray, 2004
|
*Range 120-159/80-95
Mean non-HTN 120/78 to 125/81
Mean HTN 129/82 to 141/86
|
Intake of 50-150mmol/2100kcal (1.2 to 3.5g)
|
65, 107 and 142mmol
|
-2.2 to -5.6
|
Intake of 50-150mmol/2100 kcal (1.2 to 3.5g)
|
65, 107 and 142mmol
|
-2.2 to -5.6
|
Intake of 50-150mmol/2100kcal (1.2 to 3.5g)
|
65, 107 and 142mmol
|
-2.1 to -8.3
|
|
Cheung, 2000
|
HTN >140/90
Mean HTN 157/98
Mean NTN 117/79 (121/82 M, 113/76 F)
|
N/A
|
N/A
|
N/A
|
N/A
|
N/A
|
N/A
|
N/A for study design
|
N/A for study design
|
N/A for study design
|
|
Cook, 2009
|
<125 SBP
DBP 80-89
|
N/A
|
N/A
|
N/A
|
N/A for study design
|
N/A for study design
|
N/A for study design
|
N/A
|
N/A
|
N/A
|
|
Coruzzi, 2001
|
Mean 141/95
|
N/A
|
N/A
|
N/A
|
N/A
|
N/A
|
N/A
|
+190mmol
|
Intake of 220mmol/d (5.1 g)
|
+5mmHg
|
|
Espeland, 2002
|
<125/75
125-134/75-80
135-144/80-84
<145/85
|
N/A
|
N/A
|
N/A
|
N/A
|
N/A
|
N/A
|
N/A for study design
|
N/A for study design
|
N/A for study design
|
|
Geleijnese, 2003
|
*HTN defined >140/90 vs. NTN <140/90
(Mean 144/88)
|
N/A
|
N/A
|
N/A
|
↓ of -77 (median) mmol/d (1.8g)
|
Mean urinary Na excretion: -91±52mmol/d (-2,093mg)
|
Avg -2.54/-1.96
-1.19/-1.06 (unadj)
-1.26/-1.14 (adj)
|
↓ of -77 (median) mmol/d (1.8g)
|
Mean urinary Na excretion: -91±52mmol/d (-2,093mg)
|
Avg-2.54/-1.96 -5.38/-3.85 (unadjusted)
-5.24/-3.69 (adj)
|
|
Geleijnese, 2004
|
HTN >140
|
N/A
|
N/A
|
N/A
|
N/A
|
N/A
|
N/A
|
-2.1g/d (91.3mmol)
|
Level not specified
|
Weighted ?
-2.5/-2.0
|
|
He, 2004
|
*NTN Mean 127/78
HTN Mean 149/94
|
-74mmol UNa (4.4g NaCl)
|
Usual NaCl intake: 154mmol (9.1g/d of salt), range 128 to 200mmol (7.5 to
11.8g/d salt);
↓ NaCl intake: 82mmol
(4.8g/d of salt), range: 56 to 135mmol (3.3 to 7.9g/d NaCl)
|
-2.03/-0.99
|
-74mmol UNa (4.4g NaCl)
|
Usual NaCl intake: 154mmol (9.1g/d of salt), range 128 to 200mmol (7.5 to
11.8g/d salt);
↓ NaCl intake: 82mmol
(4.8g/d of salt), range: 56 to 135mmol (3.3 to 7.9g/d NaCl)
|
-2.03/-0.99
|
78mmol UNa (4.6g NaCl)
|
Usual NaCl intake: 162mmol(9.5g)/d; Range 125-191mmol (7.4-11.2g)/d
↓ NaCl intake: 87mmol (5.1g)/d; Range 57-125mmol (3.4-7.4g)/d (form of NaCl not specified)
|
-5.06/-2.70
|
|
He, 2003
|
*HTN and NTN not defined (meta-analysis)
|
-50 to -150mmol (1.2 to 3.5g)
|
49 to 106mmol/d
|
-1.8 to -3.5/-0.8 to -1.8;
-3.5 to -7/-1.7 to-3.5; -5.4 to-10.5/-2.5 to -5.3
|
N/A
|
N/A
|
N/A
|
-50 to -150mmol (1.2 to 3.5g)
|
49 to 106 mmol/d
|
-3.6 to -5.6/-1.9 to -3.2; -7.1 to -11.2/-3.9 to -5.7; -10.7 to -16.8/ -5.8 to -9.6
|
|
He, 2001
|
HTN >140/90 vs. NTN <140/90
Mean HTN 170/196
Mean NTN 116/74
|
N/A
|
N/A
|
N/A
|
N/A
|
N/A
|
N/A
|
-10 to -20 (0.23 to 0.46g)
|
340 and 330mmol/d (from 350mmol/d)
|
-16.8/-5.7
|
|
He, 2000
|
**Inclusion: <160/80-89 Mean 122/84
|
N/A
|
N/A
|
N/A
|
Level not specified
|
148.1mmol UNa/d at Baseline; -53.5 mmol/d UNa excretion at 18mo
|
-2.7/-7.2
|
N/A
|
N/A
|
N/A
|
|
Hu & Tian, 2001
|
HTN >140/90
Mean HTN 149/92 M, 151/91 F
Mean NTN 116/76 M, 117/75 F
|
N/A
|
N/A
|
N/A
|
N/A
|
N/A
|
N/A
|
N/A for study design
|
N/A for study design
|
N/A for study design
|
|
Jessani, 2008
|
*NTN<140/90 NTN<130;Hi-Normal 130-139 |
200mEq (4.6g) actual ? in 24h-Na excretion 81mEq/d | 20 vs. 220mEq/d; 135.2mEq/d UNa on Hi and 58.4mEq/d on Lo | -1.0mmHg SBP | 200mEq (4.6g) actual ? in 24h-Na excretion 91.6 mEq/d | 20 vs. 220mEq/d 144.6mEq/d UNa on Hi and 53.0mEq/d on Lo | -6mmHg SBP | N/A | N/A | N/A |
|
Johnson, 2001
|
Defined HTN as >160/90
NTN mean 139/78
|
N/A
|
N/A
|
N/A
|
90, 140, 240, 340mmol/d (1.2 to 6.9g)
|
UNa (mmol/d):
61.3, 109.6, 185.0, 283.8mmol/d
|
+6.1/0.3, +13.7/4.0, +17.2/3.9, +16.5/5.5
|
N/A
|
N/A
|
N/A
|
|
Jurgens, 2003
|
*Definition not specified
|
Not specified
|
<120mmol/d (2.8g)
|
-1.27/-0.54
|
N/A
|
N/A
|
N/A
|
Not specified
|
<120mmol/d vs. >150mmol/d (2.8g vs. 3.5g)
|
-4.18/-1.98
|
|
Khaw, 2004
|
Mean BP 137/84 (define HTN >160 SBP) |
N/A
|
N/A
|
N/A
|
N/A for study design
|
N/A for study design
|
N/A for study design
|
N/A
|
N/A
|
N/A
|
|
Liu & Liu, 2001
|
HTN>140/90
Mean 122/73 to 135/81
|
N/A
|
N/A
|
N/A
|
N/A for study design
|
N/A for study design
|
N/A for study design
|
N/A for study design
|
N/A for study design
|
N/A for study design
|
|
Radhika, 2007
|
Defined <130/85 NTN
Mean BP for HTN vs. NTN not specified
|
N/A
|
N/A
|
N/A
|
N/A for study design
|
N/A for study design
|
N/A for study design
|
N/A for study design
|
N/A for study design
|
N/A for study design
|
|
Sacks, 2001
|
*Non-HTN 120/80
Stage 1 HTN 140-159/90-95
Mean BP 134/86
|
N/A
|
N/A
|
N/A
|
50 to 150mmol/d Na on DASH and Control (1.2 to 3.5g)
|
UNa excretion (mmol/d): 144 vs 141; 107 vs. 106; 67 vs. 64
|
From 150-100:
-2.1/1.1 vs. -1.3/-0.6; from 150 to 50: -4.6/-2.4 vs. -1.7/-1.0 DASH w/low Na ↓ SBP by 7.1mmHg
|
50 to 150mmol/d Na on DASH and Control (1.2 to 3.5g)
|
UNa excretion (mmol/d): 144 vs 141; 107 vs. 106; 67 vs. 64
|
From 150-100:
-2.1/1.1 vs. -1.3/-0.6; from 150 to 50: -4.6/-2.4 vs. -1.7/-1.0 DASH w/low Na ↓ SBP by 11.5mmHg
|
*included in >1 category (NTN, PHTN, HTN) due to inclusion of subjects in >1 category.
** includes subjects on anti-HTN medications
|
1 mEq Na = (mg *1)/23; mmol Na--> g Na= (mmol*23)/1000
At Wt Na = 23, valence = 1
Mw NaCl = 58.44
Mg Na*2.5 = mg NaCl
|