Depletion and loading methods were used for determining salt sensitivity in the clinical setting. A significant relationship of blood pressure (BP) response to salt/sodium (Na) depletion and load was observed. In adults with varying levels of BP, a dietary or an intravenous (IV) method of Na depletion (10 to 50mmol per day, three days or less) and Na loading (150 to 400mmol per day, three days or more), both with BP monitoring throughout the test period, provide strong evidence that this is an acceptable method. 

• Grade I means there is Good/Strong evidence supporting the statement;
• Grade II is Fair;
• Grade III is Limited/Weak;
• Grade IV is Expert Opinion Only;
• Grade V is Not Assignable.
• High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
• Moderate (B) means we are moderately confident in the effect estimate;
• Low (C) means our confidence in the effect estimate is limited;
• Very Low (D) means we have very little confidence in the effect estimate.
• Ungraded means a grade is not assignable.