Orlistat, an oral medication (a gastrointestinal lipase inhibitor), may be moderately effective in promoting improved adiposity (up to 12 months) as part of a comprehensive weight-management program in adolescents. However, application is limited by the common gastrointestinal adverse events.

Long-term efficacy and tolerability of orlistat as part of a comprehensive behavioral treatment program for adolescents has not been studied. Orlistat has not been studied in children younger than 12 years.

• Grade I means there is Good/Strong evidence supporting the statement;
• Grade II is Fair;
• Grade III is Limited/Weak;
• Grade IV is Expert Opinion Only;
• Grade V is Not Assignable.
• High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
• Moderate (B) means we are moderately confident in the effect estimate;
• Low (C) means our confidence in the effect estimate is limited;
• Very Low (D) means we have very little confidence in the effect estimate.
• Ungraded means a grade is not assignable.

The addition of sibutramine in the treatment of adolescents with obesity within a multi-component pediatric weight-management program may be helpful in achieving short-term (six months or less months) reductions in weight and BMI.

No studies were found using sibutramine in children under 13 years of age.

Longer-term efficacy and safety have not been thoroughly addressed.

The use of sibutramine to treat overweight is being studied in clinical trials, but it has not been approved by the FDA for pediatric use.

• Grade I means there is Good/Strong evidence supporting the statement;
• Grade II is Fair;
• Grade III is Limited/Weak;
• Grade IV is Expert Opinion Only;
• Grade V is Not Assignable.
• High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
• Moderate (B) means we are moderately confident in the effect estimate;
• Low (C) means our confidence in the effect estimate is limited;
• Very Low (D) means we have very little confidence in the effect estimate.
• Ungraded means a grade is not assignable.