Nutritive and Non-Nutritive Sweeteners

NNNS: Hyperlipidemias (2006)

• Intervention
  Can non-nutritive sweeteners (saccharin, aspartame, acesulfame-K, sucralose, neotame) be used to prevent and manage hyperlipidemias?

  • Conclusion

    Non-nutritive sweeteners have no significant effect on lipid profile in short term dietary intervention studies in adults. The evidence to determine whether non-nutritive sweeteners can be used to prevent and manage hyperlipidemia is limited.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: Can non-nutritive sweeteners (saccharin, aspartame, acesulfame-K, sucralose, neotame) be used to prevent and manage hyperlipidemias?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Cooper PL, Wahlqvist ML, Simpson RW. Sucrose versus saccharin as an added sweetener in non-insulin-dependent diabetes: short- and medium-term metabolic effects. Diabet Med. 1988 Oct; 5 (7): 676-680. PMID: 2975554.
      • Reyna N, Cano C, Bermudez VJ, et al. Sweeteners and beta-glucans improve metabolic and anthropometrics variables in well controlled type 2 diabetic patients. Am J Therapeutics. 2003; 10: 438-443.
      • Singleton MJ, Heiser C, Jamesen K, Mattes RD. Sweetener augmentation of serum triacylglycerol during a fat challenge test in humans. J Am Coll Nutr. 1999 Apr; 18 (2): 179-185.