NNNS: Hyperlipidemias (2006)
Can non-nutritive sweeteners (saccharin, aspartame, acesulfame-K, sucralose, neotame) be used to prevent and manage hyperlipidemias?
Non-nutritive sweeteners have no significant effect on lipid profile in short term dietary intervention studies in adults. The evidence to determine whether non-nutritive sweeteners can be used to prevent and manage hyperlipidemia is limited.
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
Evidence Summary: Can non-nutritive sweeteners (saccharin, aspartame, acesulfame-K, sucralose, neotame) be used to prevent and manage hyperlipidemias?
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Cooper PL, Wahlqvist ML, Simpson RW. Sucrose versus saccharin as an added sweetener in non-insulin-dependent diabetes: short- and medium-term metabolic effects. Diabet Med. 1988 Oct; 5 (7): 676-680. PMID: 2975554.
- Reyna N, Cano C, Bermudez VJ, et al. Sweeteners and beta-glucans improve metabolic and anthropometrics variables in well controlled type 2 diabetic patients. Am J Therapeutics. 2003; 10: 438-443.
- Singleton MJ, Heiser C, Jamesen K, Mattes RD. Sweetener augmentation of serum triacylglycerol during a fat challenge test in humans. J Am Coll Nutr. 1999 Apr; 18 (2): 179-185.