What is the estimated saccharin consumption level and is it within acceptable daily intake (ADI) limits?
Cross-sectional research conducted outside the United States, is consistent in finding that saccharin intakes for adults and children are below the Acceptable Daily Intake (ADI) of 5mg per kg body weight (BW), set by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), an international scientific expert committee administered jointly by the Food and Agriculture Organization of the United Nations. Persons with diabetes and young children had the highest saccharin intakes, when expressed as mg per kg body weight. Reported intakes ranged from a mean intake of 0.3mg per kg BW to a 95th percentile intake of 2.7mg per kg body weight; therefore, intake at the 95th percentile is well within the JECFA ADI.
The 2009 update did not find new studies meeting the inclusion criteria for this question; the Nutritive and Non-nutritive Sweeteners Workgroup (2009) reviewed and accepted the studies identified by the Non-nutritive Sweeteners Workgroup (2006).
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.