Nutritive and Non-Nutritive Sweeteners

NNNS: Effect of Sucralose on Appetite and Food Intake (2011)

• Intervention
  In adults, does sucralose affect food intake?

  • Conclusion

    One randomized controlled trial (Rodearmel et al, 2007) examined sucralose and food intake in adults. Sucralose does not increase food intake. Modest energy savings can result if sucralose replaces sugar-sweetened products in a form that is also lower energy.  

    This conclusion statement developed by the Nutritive and Non-nutritive Sweeteners Workgroup (2009) is consistent with the previous statement on food intake in adults developed by the Non-nutritive Sweeteners Workgroup (2006).

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In adults, does sucralose affect food intake?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Rodearmel SJ, Wyatt HR, Stroebele N, Smith SM, Ogden LG, Hill JO. Small changes in dietary sugar and physical activity as an approach to preventing excessive weight gain: The American on the Move family study. Pediatrics. 2007 Oct; 120(4): e869-e879.  
  • Search Plan and Results: Sucralose - 2009
     
  In children, does sucralose affect food intake?

  • Conclusion

    One randomized controlled trial (Rodearmel et al, 2007) examined sucralose and food intake in children. Sucralose does not increase food intake. Short-term studies suggest that modest energy savings can result if sucralose replaces sugar-sweetened products in a form that is also lower energy. Long-term studies need to assess if use of sucralose in children helps to balance energy intakes with energy expenditures. 

    This conclusion statement developed by the Nutritive and Non-nutritive Sweeteners Workgroup (2009) is consistent with the previous statement on food intake in children developed by the Non-nutritive Sweeteners Workgroup (2006).

     

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In children, does sucralose affect food intake?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Rodearmel SJ, Wyatt HR, Stroebele N, Smith SM, Ogden LG, Hill JO. Small changes in dietary sugar and physical activity as an approach to preventing excessive weight gain: The American on the Move family study. Pediatrics. 2007 Oct; 120(4): e869-e879.  
  • Search Plan and Results: Sucralose - 2009
     
  In adults, does using foods or beverages with sucralose affect appetite?

  • Conclusion

    One cross-sectional study with a small sample size of only women (Frank et al, 2008), indicates that sucralose does not affect appetite in adults. 

    This conclusion statement developed by the Nutritive and Non-nutritive Sweeteners Workgroup (2009) is consistent with the previous statement on appetite in adults developed by the Non-nutritive Sweeteners Workgroup (2006).

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In adults, does using foods or beverages with sucralose affect appetite?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Frank GK, Oberndorfer TA, Simmons AN, Paulus MP, Fudge JL, Yang TT, Kaye WH. Sucrose activates human taste pathways differently from artificial sweetener. NeuroImage. 2008; 39: 1,559-1,569.
  • Search Plan and Results: Sucralose - 2009
     
  In children, does using foods or beverages with sucralose affect appetite?

  • Conclusion

    To date, no studies were identified to evaluate the effect of sucralose on appetite in children.

  • Grade: V
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Search Plan and Results: Sucralose - 2009