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  • Intervention
    In adults, does using foods or beverages with aspartame in a calorie-restricted or ad libitum diet affect energy balance (weight)?
    • Conclusion

      Use of aspartame and aspartame-sweetened products as part of a comprehensive weight loss or maintenance program by individuals may be associated with greater weight loss and may assist individuals with weight maintenance over time.

    • Grade: I
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
    In adults, does using foods or beverages with neotame in a calorie-restricted or ad libitum diet affect energy balance?
    • Conclusion

      To date, no studies were identified to evaluate the effect of consumption of foods or beverages with neotame in a calorie-restricted or ad libitum diet on energy balance in adults.

    • Grade: V
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
    In adults, does using foods or beverages with saccharin in a calorie-restricted or ad libitum diet affect energy balance?
    • Conclusion

      Using saccharin in either a calorie-restricted or ad libitum diet will affect overall energy balance, only if the saccharin-sweetened foods are substituted for higher calorie food or beverages.

      The 2009 update did not find new studies meeting the inclusion criteria for this question; the Nutritive and Non-nutritive Sweeteners Workgroup (2009) reviewed and accepted the studies identified by the Non-nutritive Sweeteners Workgroup (2006).

       
    • Grade: III
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
    In adults, does using foods or beverages with sucralose in a calorie-restricted or ad libitum diet affect energy balance?
    • Conclusion

      One randomized controlled trial (Rodearmel et al, 2007) examined sucralose and energy balance in adults. Using sucralose in either a calorie-restricted or ad libitum diet will affect overall energy balance only if the sucralose is substituted for higher-calorie food or beverages.

      This conclusion statement developed by the Nutritive and Non-nutritive Sweeteners Workgroup (2009) is consistent with the previous statement on energy balance in adults developed by the Non-nutritive Sweeteners Workgroup (2006).

       

    • Grade: III
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.