CKD: Selenium (2018)

CKD: Selenium (2018)

• Intervention
  What is the effect of selenium supplementation on comorbidites in adults with CKD 1-5D and post-transplant?

  • Conclusion

    Selenium supplementation did not affect triglycerides, total, low-density lipoprotein, high-density lipoprotein cholesterol or homocysteine levels, but evidence was limited.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: What is the effect of selenium supplementation on comorbidites in adults with CKD 1-5D and post-transplant?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Salehi M, Sohrabi Z, Ekramzadeh M, Fallahzadeh M, Ayatollahi M, Geramizadeh B, Hassanzadeh J, Sagheb M. Selenium supplementation improves the nutritional status of hemodialysis patients: a randomized, double-blind, placebo-controlled trial. Nephrology, Dialysis, Transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2013; 28:716-23
  • Search Plan and Results: CKD: Micronutrients: Selenium (2018)
     
  What is the effect of selenium supplementation on selenium levels in adults with CKD 1-5D and post-transplant?

  • Conclusion

    Selenium supplementation increased selenium levels using a variety of dosages, types, modes and durations.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: What is the effect of selenium supplementation on selenium levels in adults with CKD 1-5D and post-transplant?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Adamowicz A, Trafikowska U, Trafikowska A, Zachara B, Manitius J. Effect of erythropoietin therapy and selenium supplementation on selected antioxidant parameters in blood of uremic patients on long-term hemodialysis. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research 2002; 8:CR202-5
      • Koenig J, Fischer M, Bulant E, Tiran B, Elmadfa I, Druml W. Antioxidant status in patients on chronic hemodialysis therapy: impact of parenteral selenium supplementation. Wiener Klinische Wochenschrift 1997; 109:13-9
      • Stockler-Pinto M, Lobo J, Moraes C, Leal V, Farage N, Rocha A, Boaventura G, Cozzolino S, Malm O, Mafra D. Effect of Brazil nut supplementation on plasma levels of selenium in hemodialysis patients: 12 months of follow-up. Journal of Renal Nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 2012; 22:434-9
      • Temple K, Smith A, Cockram D. Selenate-supplemented nutritional formula increases plasma selenium in hemodialysis patients. Journal of Renal Nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 2000; 10:16-23
      • Tonelli M, Wiebe N, Thompson S, Kinniburgh D, Klarenbach S, Walsh M, Bello A, Faruque L, Field C, Manns B, Hemmelgarn B. Trace element supplementation in hemodialysis patients: a randomized controlled trial. BMC Nephrology 2015; 16:52
      • Zachara B, Adamowicz A, Trafikowska U, Trafikowska A, Manitius J, Nartowicz E. Selenium and glutathione levels, and glutathione peroxidase activities in blood components of uremic patients on hemodialysis supplemented with selenium and treated with erythropoietin. Journal of Trace Elements in Medicine and Biology : organ of the Society for Minerals and Trace Elements (GMS) 2001; 15:201-8
  • Search Plan and Results: CKD: Micronutrients: Selenium (2018)
     
  What is the effect of selenium supplementation on inflammatory markers in adults with CKD 1-5D and post-transplant?

  • Conclusion

    Selenium supplementation improved IL-6 cytokine levels, but did not change C-reactive protein (CRP) levels compared to the placebo group.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: What is the effect of selenium supplementation on inflammatory markers in adults with CKD 1-5D and post-transplant?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Salehi M, Sohrabi Z, Ekramzadeh M, Fallahzadeh M, Ayatollahi M, Geramizadeh B, Hassanzadeh J, Sagheb M. Selenium supplementation improves the nutritional status of hemodialysis patients: a randomized, double-blind, placebo-controlled trial. Nephrology, Dialysis, Transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2013; 28:716-23
  • Search Plan and Results: CKD: Micronutrients: Selenium (2018)
     
  What is the effect of selenium supplementation on nutritional status indicators in adults with CKD 1-5D and post-transplant?

  • Conclusion

    In one RCT, oral selenium supplementation of 200 µg per day for 12 weeks decreased/improved subjective global assessment (SGA) scores and malnutrition inflammataion score (MIS), but did not affect albumin levels.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: What is the effect of selenium supplementation on nutritional status indicators in adults with CKD 1-5D and post-transplant?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Salehi M, Sohrabi Z, Ekramzadeh M, Fallahzadeh M, Ayatollahi M, Geramizadeh B, Hassanzadeh J, Sagheb M. Selenium supplementation improves the nutritional status of hemodialysis patients: a randomized, double-blind, placebo-controlled trial. Nephrology, Dialysis, Transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2013; 28:716-23
  • Search Plan and Results: CKD: Micronutrients: Selenium (2018)