What is the evidence on the progression of chronic kidney disease in patients with either diabetes types 1 or 2? (2001 CD)
Glycemic control and effective treatment of hypertension and proteinuria has been shown to be effective in delaying the onset and progression of chronic kidney disease in patients with both diabetes type 1 and 2. The Diabetes Complications and Control Trial in patients with type 1 diabetes mellitus and the United Kingdom Prospective Diabetes Study in patients with Type 2 diabetes mellitus demonstrated that intensive treatment resulting in near normal A1C reduced the incidence of microabuminuria and diabetic nephropathy.
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.