Vitamin E intake has been associated with decreased risk for cardiovascular death and nonfatal MI in observational studies (cohort and cross-sectional) and nonfatal MI in one RCT (CHAOS) in subjects with CAD.  However, three other RCT using 400 IU/d of vitamin E supplementaion for 4 to 5 years had no impact on the incidence of non-fatal or fatal CHD.

This information is from the 2001 Hyperlipidemia project. 
 

• Grade I means there is Good/Strong evidence supporting the statement;
• Grade II is Fair;
• Grade III is Limited/Weak;
• Grade IV is Expert Opinion Only;
• Grade V is Not Assignable.
• High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
• Moderate (B) means we are moderately confident in the effect estimate;
• Low (C) means our confidence in the effect estimate is limited;
• Very Low (D) means we have very little confidence in the effect estimate.
• Ungraded means a grade is not assignable.