ONC: Chemotherapy (2007)
Is there a relationship between intervention by a dietitian to enhance nutritional intake (protein, kcals) to improve tolerance and support recovery from chemotherapy for acute leukemia, and the reduction of complications associated with treatment?
One small RCT of neutral quality of 29 hospitalized patients found that nutritional care by an RD resulted in positive nutrition outcomes for patients receiving chemotherapy for acute lymphocytic and nonlymphocytic leukemia. Daily contact for assessment, education and motivation by an RD was effective in increasing body weight in the intervention group earlier and more often than in the control group (33.8% vs. 13.2%; 48.7% vs. 18.3% depending on treatment protocol). The researchers found that nutrition intake was highly correlated with body weight status. Mean daily energy intake of 23.3 ± 11.4 kcals/kg/day was associated with weight loss; 30.9 ± 13.1 kcals/kg/day was associated with stable weight; and 39.3 ± 12.2 kcals/kg/day was associated with weight gain (P < 0.0001). A significant correlation was found between nutritional intake and tumor-therapy side effects (e.g., anorexia and fatigue) (P-values <0.01).
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
Evidence Summary: Leukemia, dietitian intervention, chemotherapy, protein
Search Plan and Results: Protein and Symptoms/Complications: Chemotherapy 2006