ONC: Hematopoietic Cell Transplant (2007)
Are the calorie needs for cancer patients undergoing hematopoietic cell transplant different than the RDA?
Two studies (one positive-quality longitudinal study and one positive-quality RCT) suggest that patients receiving HCT for hematologic malignancies require, on average, 35-40 kcal per kg per day to maintain nitrogen balance and body weight during the first month post-transplant. However, energy requirements may be higher during acute GVHD and for patients receiving > 75% of their total daily energy intake via PN. These studies evaluated patients receiving myeloablative allogeneic HCT, and energy needs may be different for patients receiving non-myeloablative and/or autologous HCT.
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
Evidence Summary: Calorie Needs and HCT
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Geibig CB, Owens JP, Mirtallo JM;Bowers D, Nahikian-Nelms M, Tutschka P. Parenteral nutrition for marrow transplant recipients:evaluation of an increased nitrogen dose. Journal of Parenteral and Enteral Nutrition.1991:15(2):184-188.
- Szeluga DJ, Stuart RK, Brookmeyer R, Utermohlen V, Santos GW. Energy requirements of parenterally fed bone marrow transplant recipients. JPEN J Parenter Enteral Nutr. 1985 Mar-Apr;9(2):139-43.
Search Plan and Results: HCT: Calories, Protein, Lipids, Nutritional Intake, EN/PN 2006