CF: Fat Type

Intervention
In participants with CF, what is the relationship between fat type and mortality?
- Conclusion
  In participants with cystic fibrosis (CF), there were no studies identified that reported on the relationship between fat type and mortality.
- Grade: V
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Search Plan and Results: CF: Dietary Intake: Type of Fat 2018
In participants with CF, what is the relationship between fat type and lung function?
- Conclusion
  In adults with cystic fibrosis (CF), one small cross-sectional study found that, compared to participants with ≥50% of predicted FEV1, those with <50% of predicted FEV1 had no difference in self-reported dietary intake of SFAs or PUFAs (including EFAs). However, participants with higher lung function did have higher intake of MUFAs as % fatty acids.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In participants with CF, what is the relationship between fat type and lung function?
- Search Plan and Results: CF: Dietary Intake: Type of Fat 2018
In participants with CF, what is the relationship between fat type and quality of life?
- Conclusion
  In participants with cystic fibrosis (CF), there were no studies identified that reported on the relationship between fat type and quality of life.
- Grade: V
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Search Plan and Results: CF: Dietary Intake: Type of Fat 2018
In participants with CF, what is the relationship between fat type and anthropometric measures and growth?
- Conclusion
  In adults with cystic fibrosis (CF), one small cross-sectional study found that, compared to participants with a BMI of ≥18.5, those with BMI <18.5 reported no differences in dietary intake of SFAs, MUFAs or PUFAs (including EFAs) as percent of energy or fatty acids.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In participants with CF, what is the relationship between fat type and anthropometric measures and growth?
- Search Plan and Results: CF: Dietary Intake: Type of Fat 2018
In participants with CF, what is the relationship between fat type and morbidities (length of stay, antibiotic use)?
- Conclusion
  In participants with cystic fibrosis (CF), there were no studies identified that reported on the relationship between fat type and morbidities such as length of stay and antibiotic use.
- Grade: V
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Search Plan and Results: CF: Dietary Intake: Type of Fat 2018
In participants with CF, what is the relationship between fat type and gastrointestinal symptoms?
- Conclusion
  In participants with cystic fibrosis (CF), there were no studies identified that reported on the relationship between fat type and gastrointestinal symptoms.
- Grade: V
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Search Plan and Results: CF: Dietary Intake: Type of Fat 2018
In participants with CF, what is the relationship between fat type and lipid profile?
- Conclusion
  In children and adolescents with cystic fibrosis (CF), one cross-sectional study reported no association between dietary saturated fat intake and total cholesterol, HDL-cholesterol, LDL-cholesterol and triglyceride serum levels. There are no studies available on the relationship between dietary intake of saturated fat in childhood and serum lipid profile later in life.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In participants with CF, what is the relationship between fat type and lipid profile?
  - Detail
  - Quality Rating Summary
    For a summary of the Quality Rating results, click here.
  - Worksheets
    
    Woestenenk J, Schulkes D, Schipper H, van der Ent C, Houwen R. Dietary intake and lipid profile in children and adolescents with cystic fibrosis. Journal of Cystic Fibrosis 2017; 16:410-417
- Search Plan and Results: CF: Dietary Intake: Type of Fat 2018
In participants with CF, what is the relationship between fat type and essential fatty acid levels?
- Conclusion
  Evidence examining the relationships between dietary intake of different fat types (SFA, MUFA and PUFA, including omega-3s and omega-6s) and serum EFA levels was observational and limited. While simple correlations demonstrated no strong relationships between these variables, adjusted analysis in pediatric participants with PI (seven to 10 years of age) demonstrated that phospholipid concentration was predicted by dietary intake, with increased DHA levels and decreased T:T (indicating improved EFA status) with increased MUFA and PUFA (including EFA) intake.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In participants with CF, what is the relationship between fat type and essential fatty acid levels?
- Search Plan and Results: CF: Dietary Intake: Type of Fat 2018