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Nutritional Genomics

NG: Effect on Relevant Laboratory Measures and Blood Pressure (2018-19)

Intervention
In adults, what is the effect of incorporating results of genetic testing into nutrition counseling and care, compared to counseling or care that did not incorporate genetic results, on lipid profile?
- Conclusion
  No significant differences in cholesterol (total, LDL or HDL) or triglyceride levels were observed when results of genetic testing were incorporated into nutrition counseling or care as compared to counseling or care that did not incorporate genetic results. Findings were consistent across a variety of interventions and populations.
- Grade: II
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults, what is the effect of incorporating results of genetic testing into nutrition counseling and care, compared to compared to counseling or care that did not incorporate genetic results, on lipid profile?
- Search Plan and Results: NG: Incorporating Results of Genetic Testing into Nutrition Counseling or Care (2019)
In adults, what is the effect of different intensities of personalized nutrition counseling that incorporate results of genetic testing into nutrition counseling and care, on lipid profile?
- Conclusion
  In healthy adults of South-Asian descent, when both the intervention and comparison groups received genetic information related to myocardial infarction (MI) risk (9p21 SNP), there was no significant difference in Apolipoprotein B:A1 observed when participants received more intensive, personalized nutrition counseling.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults, what is the effect of different intensities of personalized nutrition counseling that incorporate results of genetic testing into nutrition counseling and care, on lipid profile?
  - Detail
  - Quality Rating Summary
    For a summary of the Quality Rating results, click here.
  - Worksheets
    
    Samaan Z, Schulze K, Middleton C, Irvine J,J oseph P, Mente A, Shah B, Pare G, Desai D, Anand S. South Asian heart risk assessment (SAHARA): randomized controlled trial design and pilot study. JMIR Research Protocols 2013; 2:e33
- Search Plan and Results: NG: Incorporating Results of Genetic Testing into Nutrition Counseling or Care (2019)
In adults, what is the effect of incorporating results of genetic testing into nutrition counseling and care, compared to counseling or care that did not incorporate genetic results, on glucose homeostasis measures?
- Conclusion
  No significant differences in fasting blood glucose, insulin levels or HOMA-IR were observed when results of genetic testing were incorporated into nutrition counseling or care as compared to counseling or care that did not incorporate genetic results. Findings were consistent across a variety of interventions and populations.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults, what is the effect of incorporating results of genetic testing into nutrition counseling and care, compared to counseling or care that did not incorporate genetic results, on glucose homeostasis measures?
- Search Plan and Results: NG: Incorporating Results of Genetic Testing into Nutrition Counseling or Care (2019)
In adults, what is the effect of different intensities of personalized nutrition counseling that incorporate results of genetic testing into nutrition counseling and care, on glucose homeostasis measures?
- Conclusion
  In healthy adults of South-Asian descent, when both the intervention and comparison groups received genetic information related to myocardial infarction (MI) risk (9p21 SNP), there was no significant difference in HbA1c observed when participants received more intensive, personalized nutrition counseling.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults, what is the effect of different intensities of personalized nutrition counseling that incorporate results of genetic testing into nutrition counseling and care, on glucose homeostasis measures?
  - Detail
  - Quality Rating Summary
    For a summary of the Quality Rating results, click here.
  - Worksheets
    
    Samaan Z, Schulze K, Middleton C, Irvine J,J oseph P, Mente A, Shah B, Pare G, Desai D, Anand S. South Asian heart risk assessment (SAHARA): randomized controlled trial design and pilot study. JMIR Research Protocols 2013; 2:e33
- Search Plan and Results: NG: Incorporating Results of Genetic Testing into Nutrition Counseling or Care (2019)
In adults, what is the effect of incorporating results of genetic testing into nutrition counseling and care, compared to an alternative intervention or control group, on ALT/AST levels?
- Conclusion
  In one small RCT targeting participants diagnosed with non-alcoholic fatty liver disease (NAFLD), no significant differences in AST or ALT levels were observed when results of genetic testing were incorporated into nutrition counseling or care as compared to counseling or care that did not incorporate genetic results.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults, what is the effect of incorporating results of genetic testing into nutrition counseling and care, compared to an alternative intervention or control group, on ALT/AST levels?
- Search Plan and Results: NG: Incorporating Results of Genetic Testing into Nutrition Counseling or Care (2019)
In adults, what is the effect of incorporating results of genetic testing into nutrition counseling and care, compared to an alternative intervention or control group, on blood pressure?
- Conclusion
  In healthy adults of South-Asian descent, when both the intervention and comparison groups received genetic information related to myocardial infarction (MI) risk (9p21 SNP), there was no significant difference in blood pressure observed when participants received more intensive, personalized nutrition counseling.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults, what is the effect of incorporating results of genetic testing into nutrition counseling and care, compared to an alternative intervention or control group, on blood pressure?
  - Detail
  - Quality Rating Summary
    For a summary of the Quality Rating results, click here.
  - Worksheets
    
    Samaan Z, Schulze K, Middleton C, Irvine J,J oseph P, Mente A, Shah B, Pare G, Desai D, Anand S. South Asian heart risk assessment (SAHARA): randomized controlled trial design and pilot study. JMIR Research Protocols 2013; 2:e33
- Search Plan and Results: NG: Incorporating Results of Genetic Testing into Nutrition Counseling or Care (2019)
In children, what is the effect of incorporating results of genetic testing into nutrition counseling and care, compared to an alternative intervention or control group, on relevant laboratory measures and blood pressure?
- Conclusion
  No articles examining the effect of incorporating results of genetic testing in nutrition counseling and care, compared to an alternative intervention or control group, on relevant laboratory measures or blood pressure in children met inclusion criteria for this systematic review.
- Grade: V
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.