Nutritional Genomics

NG: Effect on Anthropometric and Body Composition Measures (2018-19)

• Intervention
  In adults, what is the effect of incorporating results of genetic testing in nutrition counseling and care, compared to an alternative intervention or control group, on anthropometric measures?

  • Conclusion

    No significant differences in weight, BMI or waist circumference were observed when results of genetic testing were incorporated into nutrition counseling as compared to counseling or care that did not incorporate genetic results. Findings were consistent across a variety of interventions and populations.

  • Grade: II
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In adults, what is the effect of incorporating results of genetic testing in nutrition counseling and care, compared to an alternative intervention or control group, on anthropometric measures?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Celis-Morales C, Marsaux C, Livingstone K, Navas-Carretero S, San-Cristobal R, Fallaize R, Macready A, O'Donovan C, Woolhead C, Forster H, Kolossa S, Daniel H, Moschonis G, Mavrogianni C, Manios Y, Surwillo A, Traczyk I, Drevon C, Grimaldi K, Bouwman J, Gibney M, Walsh M, Gibney E, Brennan L, Lovegrove J, Martinez J, Saris W, Mathers J. Can genetic-based advice help you lose weight? Findings from the Food4Me European randomized controlled trial. The American Journal of Clinical Nutrition 2017; 105:1204-1213
      • Celis-Morales C, Livingstone K, Marsaux C, Macready A, Fallaize R, O'Donovan C, Woolhead C, Forster H, Walsh M, Navas-Carretero S, San-Cristobal R, Tsirigoti L, Lambrinou C, Mavrogianni C, Moschonis G, Kolossa S, Hallmann J, Godlewska M, Surwillo A, Traczyk I, Drevon C, Bouwman J, van Ommen B, Grimaldi K, Parnell L, Matthews J, Manios Y, Daniel H, Martinez J, Lovegrove J, Gibney E, Brennan L, Saris W, Gibney M, Mathers J. Effect of personalized nutrition on health-related behaviour change: evidence from the Food4Me European randomized controlled trial. International Journal of Epidemiology 2017; 46:578-588
      • Fallaize R, Celis-Morales C, Macready A, Marsaux C, Forster H, O'Donovan C, Woolhead C, San-Cristobal R, Kolossa S, Hallmann J, Mavrogianni C, Surwillo A, Livingstone K, Moschonis G, Navas-Carretero S, Walsh M, Gibney E, Brennan L, Bouwman J, Grimaldi K, Manios Y, Traczyk I, Drevon C, Martinez J, Daniel H, Saris W, Gibney M, Mathers J, Lovegrove J. The effect of the apolipoprotein E genotype on response to personalized dietary advice intervention: findings from the Food4Me randomized controlled trial. The American Journal of Clinical Nutrition 2016; 104:827-36
      • Grant R, O'Brien K, Waxler J, Vassy J, Delahanty L, Bissett L, Green R, Stember K, Guiducci C, Park E, Florez J, Meigs J. Personalized genetic risk counseling to motivate diabetes prevention: a randomized trial. Diabetes Care 2013; 36:13-9
      • Kaitlin R, Walton K, Klingel SL, Harnett A, Subedi S, Haines J, Mutch DM. Evaluating Changes in Omega-3 Fatty Acid Intake after Receiving Personal FADS1 Genetic Information: A Randomized Nutrigenetic Intervention. Nutrients 2017; 9:E240
      • Stachowska E, Ryterska K, Maciejewska D, Banaszczak M, Milkiewicz P, Milkiewicz M, Gutowska I, Ossowski P, Kaczorowska M, Jamiol-Milc D, Sabinicz A, Napierala M, Wadolowska L, Raszeja-Wyszomirska J. Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR). International Journal of Molecular Sciences 2016; 17:
      • Voils C, Coffman C, Grubber J, Edelman D, Sadeghpour A, Maciejewski M, Bolton J, Cho A, Ginsburg G, Yancy W. Does Type 2 Diabetes Genetic Testing and Counseling Reduce Modifiable Risk Factors? A Randomized Controlled Trial of Veterans. Journal of General Internal Medicine 2015; 30:1591-8
      • Wu R, Myers R, Hauser E, Vorderstrasse A, Cho A, Ginsburg G, Orlando L. Impact of genetic testing and family health history based risk counseling on behavior change and cognitive precursors for type 2 diabetes. Journal of Genetic Counseling 2017; 26:133-140
  • Search Plan and Results: NG: Incorporating Results of Genetic Testing into Nutrition Counseling or Care (2019)
     
  In adults, what is the effect of incorporating results of genetic testing in nutrition counseling and care, compared to an alternative intervention or control group, on body composition?

  • Conclusion

    In participants with NAFLD, there was a greater reduction in body fat percent when results of genetic testing were incorporated into nutrition counseling as compared to counseling or care that did not incorporate genetic results, but there was no difference in lean mass percent between groups.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In adults, what is the effect of incorporating results of genetic testing in nutrition counseling and care, compared to an alternative intervention or control group, on body composition?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Stachowska E, Ryterska K, Maciejewska D, Banaszczak M, Milkiewicz P, Milkiewicz M, Gutowska I, Ossowski P, Kaczorowska M, Jamiol-Milc D, Sabinicz A, Napierala M, Wadolowska L, Raszeja-Wyszomirska J. Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR). International Journal of Molecular Sciences 2016; 17:
  • Search Plan and Results: NG: Incorporating Results of Genetic Testing into Nutrition Counseling or Care (2019)
     
  In children, what is the effect of incorporating results of genetic testing in nutrition counseling and care, compared to an alternative intervention or control group, on anthropometric measures and body composition?

  • Conclusion

    No articles examining the effect of incorporating results of genetic testing in nutrition counseling and care, compared to an alternative intervention or control group, on anthropometric measures and body composition in children met inclusion criteria for this systematic review.

  • Grade: V
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.