DLM-SF: Endothelial Function (2021)

Intervention
In adults with atherosclerotic cardiovascular disease, what is the effect of the amount of saturated fat intake on endothelial function?
- Conclusion
  No studies were identified that evaluated effect of saturated fat intake on endothelial function in adults with atherosclerotic cardiovascular disease.
- Grade: V
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Search Plan and Results: DLM-SF: Endothelial Function and Inflammation (2021)
In adults with risk factors for atherosclerotic cardiovascular disease, what is the effect of the amount of saturated fat intake on endothelial function?
- Conclusion
  In adults with risk factors for atherosclerotic cardiovascular disease, it is unclear if reduced intake of saturated fat replaced with monounsaturated fat or carbohydrates improves endothelial function, based on limited evidence and high heterogeneity (I²=96%).
- Grade: Very Low (D)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults with risk factors for atherosclerotic cardiovascular disease, what is the effect of the amount of saturated fat intake on endothelial function?
- Search Plan and Results: DLM-SF: Endothelial Function and Inflammation (2021)
In healthy adults, what is the effect of the amount of saturated fat intake on endothelial function?
- Conclusion
  The effect of amount of saturated fat intake on endothelial function in healthy adults is uncertain due to limited available evidence.
- Grade: Very Low (D)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In healthy adults, what is the effect of the amount of saturated fat intake on endothelial outcomes?
- Search Plan and Results: DLM-SF: Endothelial Function and Inflammation (2021)